Process Improvement for the Continuous Synthesis of <i>N</i>-Benzylhydroxylamine Hydrochloride

Process Improvement for the Continuous Synthesis of <i>N</i>-Benzylhydroxylamine Hydrochloride

<i>N</i>-Benzylhydroxylamine hydrochloride serves as a critical intermediate in organic synthesis, yet traditional synthesis methods often face significant safety risks and high production costs. In this work, we developed a continuous synthesis process for <i>N</i>-benzylhyd...

Full description

Saved in:
Bibliographic Details
Main Authors: Xiaoguang Chen, Ke Chen, Guoxian Cai, Haoyue Xiang, Kai Chen, Hua Yang
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Chemistry
Subjects:
<i>N</i>-benzylhydroxylamine hydrochloride
continuous synthesis
flow chemistry
Online Access:https://www.mdpi.com/2624-8549/7/3/70
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:<i>N</i>-Benzylhydroxylamine hydrochloride serves as a critical intermediate in organic synthesis, yet traditional synthesis methods often face significant safety risks and high production costs. In this work, we developed a continuous synthesis process for <i>N</i>-benzylhydroxylamine hydrochloride, achieving an overall yield of 75% under mild and safe reaction conditions. Additionally, the implementation of solvent recovery and the recycling of hydroxylamine hydrochloride reduced the production cost to approximately $10 per kilogram. These advancements underscore the economic and practical viability of this method for large-scale industrial applications.
ISSN:2624-8549

Similar Items