Exploring the role of APRIL in autoimmunity: implications for therapeutic targeting in systemic lupus erythematosus, rheumatoid arthritis, and Sjögren’s syndrome

Exploring the role of APRIL in autoimmunity: implications for therapeutic targeting in systemic lupus erythematosus, rheumatoid arthritis, and Sjögren’s syndrome

Autoimmunity arises when the immune system erroneously attacks self-antigens, potentially resulting in organ dysfunction. This review focuses on the proliferation-inducing ligand, APRIL, and its critical role in regulating antibody-producing B cells. We explore the implications of APRIL in autoimmun...

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Bibliographic Details
Main Authors: Anastasia V. Poznyak, Elena V. Gerasimova, Nikolay A. Orekhov, Amina Eldarovna Karimova, Maria Andreevna Vergun, Ksenia Olegovna Lapshina, Vasily N. Sukhorukov, Alexander N. Orekhov
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
APRIL (TNFSF13)
BAFF
B cells
autoimmunity
rheumatoid arthritis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1523392/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1523392/full

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