The dual role of nuclear factor erythroid 2-related factor 2 in hepatocellular carcinoma: mechanisms, clinical relevance, and therapeutic opportunities

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal regulator of cellular redox balance and detoxification, critical for maintaining hepatocyte homeostasis. However, its dysregulation has emerged as a key driver in hepatocellular carcinoma (HCC), the most prevalent form of liver cancer....

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Main Authors: Houhong Wang, Shang Bian
Format: Article
Language:English
Published: Open Exploration 2025-07-01
Series:Exploration of Drug Science
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Online Access:https://www.explorationpub.com/uploads/Article/A1008119/1008119.pdf
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