Understanding the impact of amyloid beta targeted therapies on biomarkers and clinical endpoints in Alzheimer's disease

QR Code

Understanding the impact of amyloid beta targeted therapies on biomarkers and clinical endpoints in Alzheimer's disease

Abstract The Alzheimer's disease (AD) scientific field continues to make significant advances in early detection and treatments, which importantly rest on advances in our fundamental understanding of AD pathobiology and its contribution to cognitive decline. Clinical readouts of monoclonal anti...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ronald C. Petersen, Ana Graf, Alexandra S. Atkins, Miroslaw Brys, Jennifer Murphy, David S. Miller, Larisa Reyderman, Eric Siemers, Janice Smith, Maria C. Carrillo, Christopher J. Weber
Format:	Article
Language:	English
Published:	Wiley 2025-04-01
Series:	Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:	Alzheimer's disease amyloid beta protein clinical meaningfulness cognitive function dementia Research Roundtable
Online Access:	https://doi.org/10.1002/trc2.70069
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Standardization of criteria in MacCAT‐T and MacCAT‐CR for monoclonal anti–beta‐amyloid antibodies: A Delphi study
by: Jonas Karneboge, et al.
Published: (2025-04-01)

The Efficacy of Anti-amyloid Monoclonal Antibodies in Early Alzheimer’s Dementia: A Systematic Review
by: Alyaa Mostafa, et al.
Published: (2025-05-01)

Anti-amyloid Monoclonal Antibodies for Alzheimer’s Disease: A New Hope? (Review)
by: I. A. Mazerkina
Published: (2025-04-01)

Faster decline of very prodromal dementia with Lewy bodies when amyloid positive
by: Frédéric Blanc, et al.
Published: (2025-04-01)

Amyloid-beta 40 as a biomarker of cognitive impairment in acute ischemic stroke
by: Aleksey A. Kulesh, et al.
Published: (2017-10-01)

Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils
by: Maksim I. Sulatsky, et al.
Published: (2025-07-01)

Use of Model‐Based Meta‐Analysis to Inform the Design of Early Clinical Trials of Anti‐Amyloid Beta Therapies in Alzheimer's Disease
by: Sagar S. Bachhav, et al.
Published: (2025-07-01)

Three approaches to determining clinically meaningful benefit on the Cohen‐Mansfield Agitation Inventory in dementia clinical trials for agitation
by: Kathy Y. Liu, et al.
Published: (2025-04-01)

Mannose Promotes β‐Amyloid Pathology by Regulating BACE1 Glycosylation in Alzheimer's Disease
by: Chensi Liang, et al.
Published: (2025-03-01)

Amyloid tumor of the breast
by: Makiko Mori, et al.
Published: (2019-02-01)

AhR regulation of amyloid beta-induced inflammation in astrocyte cells
by: Emmanuel Ojo, et al.
Published: (2025-07-01)

Memory reconsolidation impairment by amyloid beta (1–42) and its prevention by non-competitive antagonists of NMDA receptors
by: A. A. Tiunova, et al.
Published: (2025-07-01)

Age-related cerebral amyloid angiopathy accumulation in the APPSw mouse model is associated with perivascular inflammation and brain-wide vascular and inflammatory gene and protein changes
by: Katelynn E. Krick, et al.
Published: (2025-09-01)

Diagnostic Challenge in Frontal Variant Alzheimer's Disease With Low Amyloid‐β PET Retention
by: Ryosuke Shimasaki, et al.
Published: (2025-07-01)

Recent Advances in Amyloids Structural Studies and Thin Film Applications
by: Eugenia Pechkova, et al.
Published: (2025-07-01)

Role of neuronal fabp in autophagy and amyloid-β pathology in a Drosophila model of Alzheimer disease
by: Byoungyun Choi, et al.
Published: (2025-12-01)

How do we put meaning into meaningful benefit? Perspectives from the lived experience
by: Russ Paulsen, et al.
Published: (2025-04-01)

A Pilot Study on Blood Concentration of β-Amyloid (40 and 42) and Phospho-Tau 181 in Horses
by: Valentina Gazzano, et al.
Published: (2025-06-01)

Report of a case of spontaneous cerebral hemorrhage due to amyloid angiopathy
by: Yifan Wang, et al.
Published: (2025-07-01)

Measuring time saved in Alzheimer's disease: What is a meaningful slowing of progression?
by: Krista Lanctot, et al.
Published: (2025-04-01)

Optical Taxonomic Signal and the Diagnosis of Alzheimer's Disease
by: Frank A. Greco, et al.
Published: (2025-01-01)

Inhibition of BET proteins modulates amyloid-beta accumulation and cognitive performance in middle-aged mice prenatally exposed to maternal immune activation
by: Marta Matuszewska, et al.
Published: (2025-07-01)

TWO APPROACHES IN COMPUTER SCIENCE
by: A. A. Moskvitin, et al.
Published: (2022-08-01)

Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from China
by: Xiang‐Sha Yin, et al.
Published: (2025-04-01)

System readiness and the patient care pathway for Alzheimer's disease diagnosis and treatment
by: B. Joy Snider, et al.
Published: (2025-04-01)

Protection against prolonged pneumococcal infection involves structural changes in C-reactive protein and subsequent binding to both phosphocholine and amyloids on the bacterial surface
by: Alok Agrawal, et al.
Published: (2025-07-01)

Role of berberine in Alzheimer&rsquo;s disease
by: Cai Z, et al.
Published: (2016-10-01)

Amyloid Cardiomyopathy: Review of A Fatal Case Report
by: O. V. Soldatova, et al.
Published: (2025-05-01)

A Multidimensional Concept of Meaningful Work: Theoretical Framework
by: Inga Iždonaitė-Medžiūnienė, et al.
Published: (2023-11-01)

The diagnostic value plasma procalcitonin (PCT) and serum amyloid A protein (SAA) in children with mycoplasma pneumonia
by: Wang Baoyue, et al.
Published: (2025-01-01)

Amyloid-induced mineralization: From biological systems to biomimetic materials
by: Congdi Zhang, et al.
Published: (2025-09-01)

Primary pulmonary mucosa-associated lymphoid tissue lymphoma with amyloid light chain-type amyloidosis
by: Shuta Ohara, et al.
Published: (2019-06-01)

Anti-Amyloid Aggregation Effects of Gobaishi (<i>Galla chinensis</i>) and Its Active Constituents
by: Sharmin Akter, et al.
Published: (2025-06-01)

Nose-to-brain delivery of targeted lipid nanoparticles as two-pronged β-amyloid nanoscavenger for Alzheimer's disease therapy
by: Yanyan Xu, et al.
Published: (2025-06-01)

Enhancing Motivation through Work Meaningfulness
by: Jarred Shellhouse, et al.
Published: (2019-03-01)

Enhancing Motivation through Work Meaningfulness
by: Jarred Shellhouse, et al.
Published: (2019-03-01)

Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer’s disease and SKNMC cells co-culture model
by: Caixia Xiang, et al.
Published: (2024-12-01)

NON-VAL30MET-TRANSTHYRETIN AMYLOID CARDIOMYOPATHY. LITERATURE REVIEW AND CLINICAL CASE
by: A. Ya. Gudkova, et al.
Published: (2018-03-01)

Amyloid β (Aβ) inhibits retinal angiogenesis in Alzheimer's disease via LncRNA-XIST/miRNA-126-5p/VEGF axis
by: Bin Wang, et al.
Published: (2025-07-01)

Generating real‐world evidence in early Alzheimer's disease: Considerations for applying the target trial emulation framework to study the safety of anti‐amyloid therapies
by: Xiaojuan Li, et al.
Published: (2025-04-01)