The Modulating Effect of Perfluorane on the Ratio of Pro- to Antioxidative Systems in Different Organs
The experiment demonstrated the modulating effect of the antihypoxic agent perfluorane, a blood substitute having multifunctional properties, on the ratio of pro- to antioxidative systems in different organs. In the heart, perfluorane prevented the activation of free radical oxidation under stress,...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2006-02-01
|
| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/1198 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839578577701437440 |
|---|---|
| author | A. G. Zhukova T. G. Sazontova I. V. Arkadyeva V. V Moroz |
| author_facet | A. G. Zhukova T. G. Sazontova I. V. Arkadyeva V. V Moroz |
| author_sort | A. G. Zhukova |
| collection | DOAJ |
| description | The experiment demonstrated the modulating effect of the antihypoxic agent perfluorane, a blood substitute having multifunctional properties, on the ratio of pro- to antioxidative systems in different organs. In the heart, perfluorane prevented the activation of free radical oxidation under stress, by increasing the activity of superoxide dismutase (SOD) and other enzymes of antioxidative defense. In the liver less resistant to free radical tissue oxidation, acute stress lowered the activity of SOD by 37% during administration of perfluorane, which was followed by the unchanged baseline level of oxidation products and by the hypersensitivity of membranous structures to induction of free radical oxidation. Under stress, proxanol in the heart and liver protected membranous structures from the influence of APK-induced damaging factors without substantially activating the enzymes of antioxidative defense. It is concluded that it is necessary to choose the optimum dosage of the drugs modulating the ratio of pro- to antioxidants in the cell, by taking into account the state of organs that are most sensitive to active oxygen forms. |
| format | Article |
| id | doaj-art-15ffa5cdfa8f46d9976e7cd82f758cc1 |
| institution | Matheson Library |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2006-02-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-15ffa5cdfa8f46d9976e7cd82f758cc12025-08-04T10:40:36ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102006-02-0121475010.15360/1813-9779-2006-1-47-501198The Modulating Effect of Perfluorane on the Ratio of Pro- to Antioxidative Systems in Different OrgansA. G. Zhukova0T. G. Sazontova1I. V. Arkadyeva2V. V Moroz3Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical SciencesM. V. Lomonosov Moscow State University, MoscowResearch Institute of General Pathology and Pathophysiology, Russian Academy of Medical SciencesResearch Institute of General Reanimatology, Russian Academy of Medical SciencesThe experiment demonstrated the modulating effect of the antihypoxic agent perfluorane, a blood substitute having multifunctional properties, on the ratio of pro- to antioxidative systems in different organs. In the heart, perfluorane prevented the activation of free radical oxidation under stress, by increasing the activity of superoxide dismutase (SOD) and other enzymes of antioxidative defense. In the liver less resistant to free radical tissue oxidation, acute stress lowered the activity of SOD by 37% during administration of perfluorane, which was followed by the unchanged baseline level of oxidation products and by the hypersensitivity of membranous structures to induction of free radical oxidation. Under stress, proxanol in the heart and liver protected membranous structures from the influence of APK-induced damaging factors without substantially activating the enzymes of antioxidative defense. It is concluded that it is necessary to choose the optimum dosage of the drugs modulating the ratio of pro- to antioxidants in the cell, by taking into account the state of organs that are most sensitive to active oxygen forms.https://www.reanimatology.com/rmt/article/view/1198perfluoraneproxanolstressfree radical oxidationantioxidative enzymes |
| spellingShingle | A. G. Zhukova T. G. Sazontova I. V. Arkadyeva V. V Moroz The Modulating Effect of Perfluorane on the Ratio of Pro- to Antioxidative Systems in Different Organs Общая реаниматология perfluorane proxanol stress free radical oxidation antioxidative enzymes |
| title | The Modulating Effect of Perfluorane on the Ratio of Pro- to Antioxidative Systems in Different Organs |
| title_full | The Modulating Effect of Perfluorane on the Ratio of Pro- to Antioxidative Systems in Different Organs |
| title_fullStr | The Modulating Effect of Perfluorane on the Ratio of Pro- to Antioxidative Systems in Different Organs |
| title_full_unstemmed | The Modulating Effect of Perfluorane on the Ratio of Pro- to Antioxidative Systems in Different Organs |
| title_short | The Modulating Effect of Perfluorane on the Ratio of Pro- to Antioxidative Systems in Different Organs |
| title_sort | modulating effect of perfluorane on the ratio of pro to antioxidative systems in different organs |
| topic | perfluorane proxanol stress free radical oxidation antioxidative enzymes |
| url | https://www.reanimatology.com/rmt/article/view/1198 |
| work_keys_str_mv | AT agzhukova themodulatingeffectofperfluoraneontheratioofprotoantioxidativesystemsindifferentorgans AT tgsazontova themodulatingeffectofperfluoraneontheratioofprotoantioxidativesystemsindifferentorgans AT ivarkadyeva themodulatingeffectofperfluoraneontheratioofprotoantioxidativesystemsindifferentorgans AT vvmoroz themodulatingeffectofperfluoraneontheratioofprotoantioxidativesystemsindifferentorgans AT agzhukova modulatingeffectofperfluoraneontheratioofprotoantioxidativesystemsindifferentorgans AT tgsazontova modulatingeffectofperfluoraneontheratioofprotoantioxidativesystemsindifferentorgans AT ivarkadyeva modulatingeffectofperfluoraneontheratioofprotoantioxidativesystemsindifferentorgans AT vvmoroz modulatingeffectofperfluoraneontheratioofprotoantioxidativesystemsindifferentorgans |