MILDRONATE THERAPY IN PATIENTS WITH CHRONIC HEART FAILURE, TYPE 2 DIABETES MELLITUS AND AUTONOMOUS CARDIAC NEUROPATHY
In total, 60 45-70-year-old patients with Functional Class II-III chronic heart failure (CHF) after a myocardial infarction, compensated or sub-compensated Type 2 diabetes mellitus (DM-2), and autonomous cardiac neuropathy were examined. The basis therapy included enalapril, bisoprolol, aspirin, and...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2009-06-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1357 |
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| Summary: | In total, 60 45-70-year-old patients with Functional Class II-III chronic heart failure (CHF) after a myocardial infarction, compensated or sub-compensated Type 2 diabetes mellitus (DM-2), and autonomous cardiac neuropathy were examined. The basis therapy included enalapril, bisoprolol, aspirin, and simvastatin. Anti-diabetic treatment included gliclazide and/or metformin. Group I (n=30) additionally received mildronate (1 g/d). The study lasted for 16 weeks and focused on the dynamics of heart rate variability, quality of life, systolic and diastolic cardiac function, carbohydrate and lipid metabolism parameters. In DM-2 patients with autonomous cardiac neuropathy, a cardioprotective agent mildronate, as a part of complex CHF therapy, improved cardiac autonomous function, quality of life, carbohydrate and lipid metabolism, demonstrated anti-ischemic effect, and reduced CHF clinical manifestations. |
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| ISSN: | 1560-4071 2618-7620 |