Nonselective beta-blockers in primary prophylaxis of esophageal variceal bleeding in patients with ascites waitlisted for liver transplantation
Objective: to determine the efficacy of non-selective beta-blockers (NSBBs) in the primary prevention of bleeding esophageal varices and to assess their impact on the survival of patients with ascites enrolled in the liver transplant waiting list (LTWL).Materials and methods. We carried out a retros...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2023-04-01
|
| Series: | Вестник трансплантологии и искусственных органов |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/1593 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839573777396006912 |
|---|---|
| author | V. L. Korobka V. D. Pasechnikov R. V. Korobka E. S. Pak A. M. Shapovalov D. V. Pasechnikov |
| author_facet | V. L. Korobka V. D. Pasechnikov R. V. Korobka E. S. Pak A. M. Shapovalov D. V. Pasechnikov |
| author_sort | V. L. Korobka |
| collection | DOAJ |
| description | Objective: to determine the efficacy of non-selective beta-blockers (NSBBs) in the primary prevention of bleeding esophageal varices and to assess their impact on the survival of patients with ascites enrolled in the liver transplant waiting list (LTWL).Materials and methods. We carried out a retrospective comparative study of cirrhotic patients with severe ascites and esophageal varices without bleeding before enrollment in the LTWL. Primary prophylaxis of variceal bleeding included the use of NSBBs (n = 97, group 1). These drugs were not used in the other patients (n = 91, group 2).Results. There were no significant differences between the groups in terms of clinical, laboratory and demographic parameters, MELD scores and Child-Turcotte-Pugh (CTP) classes for cirrhosis. Patient groups included in the study had no significant differences with respect to incidence of medium- and large-sized varices and incidence of severe ascites. Bleeding incidence was significantly lower in the NSBBs group than in the non-NSBBs group (52.6% and 95.6%, respectively, p = 0.0001).Conclusion. NSBBs constitute an efficacious therapy in primary prophylaxis of esophageal variceal bleeding, thereby saving life and preventing delisting of patients with ascites from the LTWL. |
| format | Article |
| id | doaj-art-153a0c7f70d547efa6b38640f76b0b83 |
| institution | Matheson Library |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2023-04-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-153a0c7f70d547efa6b38640f76b0b832025-08-04T14:02:12ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912023-04-01251687610.15825/1995-1191-2023-1-68-761169Nonselective beta-blockers in primary prophylaxis of esophageal variceal bleeding in patients with ascites waitlisted for liver transplantationV. L. Korobka0V. D. Pasechnikov1R. V. Korobka2E. S. Pak3A. M. Shapovalov4D. V. Pasechnikov5Rostov Regional Clinical Hospital; Rostov State Medical UniversityStavropol State Medical UniversityRostov Regional Clinical Hospital; Rostov State Medical UniversityRostov Regional Clinical Hospital; Rostov State Medical UniversityRostov Regional Clinical HospitalStavropol State Medical UniversityObjective: to determine the efficacy of non-selective beta-blockers (NSBBs) in the primary prevention of bleeding esophageal varices and to assess their impact on the survival of patients with ascites enrolled in the liver transplant waiting list (LTWL).Materials and methods. We carried out a retrospective comparative study of cirrhotic patients with severe ascites and esophageal varices without bleeding before enrollment in the LTWL. Primary prophylaxis of variceal bleeding included the use of NSBBs (n = 97, group 1). These drugs were not used in the other patients (n = 91, group 2).Results. There were no significant differences between the groups in terms of clinical, laboratory and demographic parameters, MELD scores and Child-Turcotte-Pugh (CTP) classes for cirrhosis. Patient groups included in the study had no significant differences with respect to incidence of medium- and large-sized varices and incidence of severe ascites. Bleeding incidence was significantly lower in the NSBBs group than in the non-NSBBs group (52.6% and 95.6%, respectively, p = 0.0001).Conclusion. NSBBs constitute an efficacious therapy in primary prophylaxis of esophageal variceal bleeding, thereby saving life and preventing delisting of patients with ascites from the LTWL.https://journal.transpl.ru/vtio/article/view/1593liver transplant waiting listascitesbleedingnonselective beta-blockers |
| spellingShingle | V. L. Korobka V. D. Pasechnikov R. V. Korobka E. S. Pak A. M. Shapovalov D. V. Pasechnikov Nonselective beta-blockers in primary prophylaxis of esophageal variceal bleeding in patients with ascites waitlisted for liver transplantation Вестник трансплантологии и искусственных органов liver transplant waiting list ascites bleeding nonselective beta-blockers |
| title | Nonselective beta-blockers in primary prophylaxis of esophageal variceal bleeding in patients with ascites waitlisted for liver transplantation |
| title_full | Nonselective beta-blockers in primary prophylaxis of esophageal variceal bleeding in patients with ascites waitlisted for liver transplantation |
| title_fullStr | Nonselective beta-blockers in primary prophylaxis of esophageal variceal bleeding in patients with ascites waitlisted for liver transplantation |
| title_full_unstemmed | Nonselective beta-blockers in primary prophylaxis of esophageal variceal bleeding in patients with ascites waitlisted for liver transplantation |
| title_short | Nonselective beta-blockers in primary prophylaxis of esophageal variceal bleeding in patients with ascites waitlisted for liver transplantation |
| title_sort | nonselective beta blockers in primary prophylaxis of esophageal variceal bleeding in patients with ascites waitlisted for liver transplantation |
| topic | liver transplant waiting list ascites bleeding nonselective beta-blockers |
| url | https://journal.transpl.ru/vtio/article/view/1593 |
| work_keys_str_mv | AT vlkorobka nonselectivebetablockersinprimaryprophylaxisofesophagealvaricealbleedinginpatientswithasciteswaitlistedforlivertransplantation AT vdpasechnikov nonselectivebetablockersinprimaryprophylaxisofesophagealvaricealbleedinginpatientswithasciteswaitlistedforlivertransplantation AT rvkorobka nonselectivebetablockersinprimaryprophylaxisofesophagealvaricealbleedinginpatientswithasciteswaitlistedforlivertransplantation AT espak nonselectivebetablockersinprimaryprophylaxisofesophagealvaricealbleedinginpatientswithasciteswaitlistedforlivertransplantation AT amshapovalov nonselectivebetablockersinprimaryprophylaxisofesophagealvaricealbleedinginpatientswithasciteswaitlistedforlivertransplantation AT dvpasechnikov nonselectivebetablockersinprimaryprophylaxisofesophagealvaricealbleedinginpatientswithasciteswaitlistedforlivertransplantation |