Engineering Yarrowia lipolytica for high-level β-elemene production via combinatorial metabolic strategies

Engineering Yarrowia lipolytica for high-level β-elemene production via combinatorial metabolic strategies

β-Elemene, a pharmacologically active sesquiterpene derived from the traditional Chinese medicinal herb Curcuma wenyujin, exhibits broad-spectrum anti-tumor and anti-inflammatory activities. Currently, its commercial production relies heavily on plant extraction, a process associated with high costs...

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Bibliographic Details
Main Authors: Mingyu Dai, Qingyi Cao, Shuanglong Jia, Jiang Chen, Hui-Ying Xu, Bang-Ce Ye, Wei-Bing Liu, Ying Zhou
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-12-01
Series:Synthetic and Systems Biotechnology
Subjects:
β-elemene
Germacrene A
Sesquiterpene
Metabolic engineering
Yarrowia lipolytica
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X25000924
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http://www.sciencedirect.com/science/article/pii/S2405805X25000924

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