Safety of Herbal Medicines: Clinical and Pharmacological Aspects
Herbal medicines make up a large part of all medicinal products in the Russian market. Complex combinations of biologically active substances that are used as components in herbal medicines not only determine their therapeutic efficacy, but can also cause adverse reactions. The aim of this review wa...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»
2020-12-01
|
| Series: | Безопасность и риск фармакотерапии |
| Subjects: | |
| Online Access: | https://www.risksafety.ru/jour/article/view/193 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839581755472871424 |
|---|---|
| author | O. A. Demidova V. V. Arkhipov M. V. Zhuravleva T. A. Alexandrova A. A. Alexandrov |
| author_facet | O. A. Demidova V. V. Arkhipov M. V. Zhuravleva T. A. Alexandrova A. A. Alexandrov |
| author_sort | O. A. Demidova |
| collection | DOAJ |
| description | Herbal medicines make up a large part of all medicinal products in the Russian market. Complex combinations of biologically active substances that are used as components in herbal medicines not only determine their therapeutic efficacy, but can also cause adverse reactions. The aim of this review was to analyse data on adverse effects of herbal medicines, and reasons and mechanisms behind their development. Special attention should be given to hepatotoxic and nephrotoxic effects of biologically active substances that are used as components in herbal medicines, because liver and kidney failure may lead to life-threatening conditions. The paper addresses hepatic adverse effects, including sinusoidal obstruction syndrome, caused by toxic biologically active substances of the pyrrolizidine alkaloids group. The paper summarises data on herbal medicines and toxic biologically active substances causing acute kidney injury and chronic kidney disease. It analyses potential clinically significant interactions that may occur during co-use of herbal and other types of medicines due to their pharmacokinetic and pharmacodynamic interactions. Further research involving collection, systematisation, and analysis of adverse effects of herbal medicines used alone or in combination with other medicinal products is needed to improve the safety of pharmacotherapy. |
| format | Article |
| id | doaj-art-133e64c6f15c46e8ab071b7390b112c0 |
| institution | Matheson Library |
| issn | 2312-7821 2619-1164 |
| language | Russian |
| publishDate | 2020-12-01 |
| publisher | Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» |
| record_format | Article |
| series | Безопасность и риск фармакотерапии |
| spelling | doaj-art-133e64c6f15c46e8ab071b7390b112c02025-08-04T10:16:31ZrusMinistry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»Безопасность и риск фармакотерапии2312-78212619-11642020-12-018416517710.30895/2312-7821-2020-8-4-165-177172Safety of Herbal Medicines: Clinical and Pharmacological AspectsO. A. Demidova0V. V. Arkhipov1M. V. Zhuravleva2T. A. Alexandrova3A. A. Alexandrov4Scientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsHerbal medicines make up a large part of all medicinal products in the Russian market. Complex combinations of biologically active substances that are used as components in herbal medicines not only determine their therapeutic efficacy, but can also cause adverse reactions. The aim of this review was to analyse data on adverse effects of herbal medicines, and reasons and mechanisms behind their development. Special attention should be given to hepatotoxic and nephrotoxic effects of biologically active substances that are used as components in herbal medicines, because liver and kidney failure may lead to life-threatening conditions. The paper addresses hepatic adverse effects, including sinusoidal obstruction syndrome, caused by toxic biologically active substances of the pyrrolizidine alkaloids group. The paper summarises data on herbal medicines and toxic biologically active substances causing acute kidney injury and chronic kidney disease. It analyses potential clinically significant interactions that may occur during co-use of herbal and other types of medicines due to their pharmacokinetic and pharmacodynamic interactions. Further research involving collection, systematisation, and analysis of adverse effects of herbal medicines used alone or in combination with other medicinal products is needed to improve the safety of pharmacotherapy.https://www.risksafety.ru/jour/article/view/193herbal medicineadverse reactionssafe usepyrrolizidine alkaloidsaristolochic acidstoxicitydrug interactions |
| spellingShingle | O. A. Demidova V. V. Arkhipov M. V. Zhuravleva T. A. Alexandrova A. A. Alexandrov Safety of Herbal Medicines: Clinical and Pharmacological Aspects Безопасность и риск фармакотерапии herbal medicine adverse reactions safe use pyrrolizidine alkaloids aristolochic acids toxicity drug interactions |
| title | Safety of Herbal Medicines: Clinical and Pharmacological Aspects |
| title_full | Safety of Herbal Medicines: Clinical and Pharmacological Aspects |
| title_fullStr | Safety of Herbal Medicines: Clinical and Pharmacological Aspects |
| title_full_unstemmed | Safety of Herbal Medicines: Clinical and Pharmacological Aspects |
| title_short | Safety of Herbal Medicines: Clinical and Pharmacological Aspects |
| title_sort | safety of herbal medicines clinical and pharmacological aspects |
| topic | herbal medicine adverse reactions safe use pyrrolizidine alkaloids aristolochic acids toxicity drug interactions |
| url | https://www.risksafety.ru/jour/article/view/193 |
| work_keys_str_mv | AT oademidova safetyofherbalmedicinesclinicalandpharmacologicalaspects AT vvarkhipov safetyofherbalmedicinesclinicalandpharmacologicalaspects AT mvzhuravleva safetyofherbalmedicinesclinicalandpharmacologicalaspects AT taalexandrova safetyofherbalmedicinesclinicalandpharmacologicalaspects AT aaalexandrov safetyofherbalmedicinesclinicalandpharmacologicalaspects |