From Menopause to Molecular Dysregulation: Proteomic Insights into Obesity-Related Pathways—A Narrative Review
Peri- and postmenopausal women often experience unexplained weight gain despite maintaining consistent dietary and lifestyle habits. While the biological mechanisms underlying this phenomenon remain poorly understood, physiological and pathophysiological changes during the menopausal transition are...
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2025-06-01
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| author | Basant E. Katamesh Jithinraj Edakkanambeth Varayil Nina Pillai Ann Vincent |
| author_facet | Basant E. Katamesh Jithinraj Edakkanambeth Varayil Nina Pillai Ann Vincent |
| author_sort | Basant E. Katamesh |
| collection | DOAJ |
| description | Peri- and postmenopausal women often experience unexplained weight gain despite maintaining consistent dietary and lifestyle habits. While the biological mechanisms underlying this phenomenon remain poorly understood, physiological and pathophysiological changes during the menopausal transition are likely contributors. Proteomic profiling holds potential for revealing key molecular pathways involved in the pathogenesis of obesity in this population. This review synthesizes current evidence on proteomic alterations linked to overweight and obesity in peri- and postmenopausal women. A structured literature search was performed across Ovid MEDLINE<sup>®</sup>, EMBASE, the Cochrane Library, and Scopus for studies published between October 2010 and March 2025. Eligible studies included original research involving overweight or obese peri- or postmenopausal women that reported proteomic data. Extracted information encompassed study design, participant characteristics, sample types, and proteomic findings. Identified proteins were cross-referenced with a prior review of consistently dysregulated proteins in obesity. Five studies met the inclusion criteria, collectively revealing consistent proteomic patterns associated with inflammation, metabolic dysfunction, and endothelial dysregulation. These included C-reactive protein, Tissue necrotic factor-alpha, interleukins, adiponectin, and endocan. Notably, one study demonstrated that weight loss led to reductions in IL-6, IL-1 receptor antagonist, and CRP, suggesting that obesity-related inflammation may be at least partially reversible. This review provides preliminary evidence linking chronic inflammation, metabolic dysregulation, and vascular stress to obesity in peri- and postmenopausal women. These proteomic signatures enhance understanding of menopausal weight gain and highlight the potential of proteomics to guide personalized interventions. However, larger, well-designed prospective studies are needed to confirm these associations and clarify causal pathways. |
| format | Article |
| id | doaj-art-12e605bce96a4f2fb3461125ba052d92 |
| institution | Matheson Library |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-12e605bce96a4f2fb3461125ba052d922025-07-25T13:15:32ZengMDPI AGBiomedicines2227-90592025-06-01137155810.3390/biomedicines13071558From Menopause to Molecular Dysregulation: Proteomic Insights into Obesity-Related Pathways—A Narrative ReviewBasant E. Katamesh0Jithinraj Edakkanambeth Varayil1Nina Pillai2Ann Vincent3Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USADepartment of Family Medicine, Mayo Clinic, Rochester, MN 55905, USAEdward Via College of Osteopathic Medicine, Virginia Campus (VCOM–VA), Blacksburg, VA 24060, USADivision of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USAPeri- and postmenopausal women often experience unexplained weight gain despite maintaining consistent dietary and lifestyle habits. While the biological mechanisms underlying this phenomenon remain poorly understood, physiological and pathophysiological changes during the menopausal transition are likely contributors. Proteomic profiling holds potential for revealing key molecular pathways involved in the pathogenesis of obesity in this population. This review synthesizes current evidence on proteomic alterations linked to overweight and obesity in peri- and postmenopausal women. A structured literature search was performed across Ovid MEDLINE<sup>®</sup>, EMBASE, the Cochrane Library, and Scopus for studies published between October 2010 and March 2025. Eligible studies included original research involving overweight or obese peri- or postmenopausal women that reported proteomic data. Extracted information encompassed study design, participant characteristics, sample types, and proteomic findings. Identified proteins were cross-referenced with a prior review of consistently dysregulated proteins in obesity. Five studies met the inclusion criteria, collectively revealing consistent proteomic patterns associated with inflammation, metabolic dysfunction, and endothelial dysregulation. These included C-reactive protein, Tissue necrotic factor-alpha, interleukins, adiponectin, and endocan. Notably, one study demonstrated that weight loss led to reductions in IL-6, IL-1 receptor antagonist, and CRP, suggesting that obesity-related inflammation may be at least partially reversible. This review provides preliminary evidence linking chronic inflammation, metabolic dysregulation, and vascular stress to obesity in peri- and postmenopausal women. These proteomic signatures enhance understanding of menopausal weight gain and highlight the potential of proteomics to guide personalized interventions. However, larger, well-designed prospective studies are needed to confirm these associations and clarify causal pathways.https://www.mdpi.com/2227-9059/13/7/1558menopauseoverweightobesityproteomics |
| spellingShingle | Basant E. Katamesh Jithinraj Edakkanambeth Varayil Nina Pillai Ann Vincent From Menopause to Molecular Dysregulation: Proteomic Insights into Obesity-Related Pathways—A Narrative Review Biomedicines menopause overweight obesity proteomics |
| title | From Menopause to Molecular Dysregulation: Proteomic Insights into Obesity-Related Pathways—A Narrative Review |
| title_full | From Menopause to Molecular Dysregulation: Proteomic Insights into Obesity-Related Pathways—A Narrative Review |
| title_fullStr | From Menopause to Molecular Dysregulation: Proteomic Insights into Obesity-Related Pathways—A Narrative Review |
| title_full_unstemmed | From Menopause to Molecular Dysregulation: Proteomic Insights into Obesity-Related Pathways—A Narrative Review |
| title_short | From Menopause to Molecular Dysregulation: Proteomic Insights into Obesity-Related Pathways—A Narrative Review |
| title_sort | from menopause to molecular dysregulation proteomic insights into obesity related pathways a narrative review |
| topic | menopause overweight obesity proteomics |
| url | https://www.mdpi.com/2227-9059/13/7/1558 |
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