Infectious Properties of Avian Influenza A/H5N1 Virus Strains Studied by means of Experiments on Mice

Infectious Properties of Avian Influenza A/H5N1 Virus Strains Studied by means of Experiments on Mice

The studied strains of avian influenza virus A/H5N1 (AIV), isolated in the territory of the Russian Federation and CIS countries, can be classified into three groups according to their virulence for mice after intranasal and aerosol challenging: highly virulent strains [50 % aerosol lethal dose (ALD...

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Main Authors: A. A. Sergeev, O. V. P`yankov, O. K. Demina, O. G. P`yankova, E. I. Ryabchikova, A. P. Agafonov, A. N. Sergeev
Format: Article
Language:Russian
Published: Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” 2011-06-01
Series:Проблемы особо опасных инфекций
Subjects:
avian influenza virus a/h5n1
mouse
intranasal challenging
aerosol challenging
50 % lethal dose
respiratory tract
target-cell for virus
Online Access:https://journal.microbe.ru/jour/article/view/677
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Summary:The studied strains of avian influenza virus A/H5N1 (AIV), isolated in the territory of the Russian Federation and CIS countries, can be classified into three groups according to their virulence for mice after intranasal and aerosol challenging: highly virulent strains [50 % aerosol lethal dose (ALD50) - 4,5 lg EID50] - A/Turkey/Suzdalka/Nov-1/2005 and A/Chicken/Suzdalka/Nov-11/2005. Registered is the high degree of correlation (r = 0,89 ) between the indexes of virulence of the strains, obtained by means of intranasal and aerosol challenging of mice. The primary target-cells in mice, respiratory-infected by AIV, are the respiratory tract ciliated cells and pneumonocytes of I, II types.
ISSN:0370-1069
2658-719X

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