Neoadjuvant radiotherapy for myxoid liposarcomas: Oncologic outcomes and histopathologic correlations
Objective: The aim of this study was to evaluate the histopathological features of primary extremity myxoid liposarcoma before and after neoadjuvant radiation therapy, and to evaluate the oncological outcomes of the patients. Methods: The study included 23 patients (16 men and 7 women with a mean ag...
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2017-10-01
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| Series: | Acta Orthopaedica et Traumatologica Turcica |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1017995X17301815 |
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| author | Ahmet Salduz Buğra Alpan Natig Valiyev Emre Özmen Ayça İribaş Fulya Ağaoğlu Aysel Bayram Bilge Bilgiç Harzem Özger |
| author_facet | Ahmet Salduz Buğra Alpan Natig Valiyev Emre Özmen Ayça İribaş Fulya Ağaoğlu Aysel Bayram Bilge Bilgiç Harzem Özger |
| author_sort | Ahmet Salduz |
| collection | DOAJ |
| description | Objective: The aim of this study was to evaluate the histopathological features of primary extremity myxoid liposarcoma before and after neoadjuvant radiation therapy, and to evaluate the oncological outcomes of the patients. Methods: The study included 23 patients (16 men and 7 women with a mean age of 43 (24–69) years) with primary myxoid liposarcoma of the extremities, who were treated between January 1998 and December 2015. Inclusion criteria were histopathological confirmation of the diagnosis with both the initial biopsy and the resection specimen, and having undergone neoadjuvant radiotherapy. Demographic, clinical and histopathological data were evaluated. Results: Over a mean follow-up time of 55.2 (8–139) months, 5 patients (21.7%) died secondary to disease progression, leaving 18 patients (78.3%) still alive at the time of last follow-up. Only one patient (4%) experienced local recurrence and six (26%) patients developed distant metastases. Disease-free survival at 5 and 10 years were 66%; whereas, overall patient survival at 5 and 10 years were 78.1% and 71.0%, respectively. Tumor size (>15 cm) and presence of metastasis were significantly associated with increased overall mortality. On histopathology, necrosis was present in 12/23 resection specimens. Hyalinization/fibrosis and residual viable tumor was present in all specimens. Adipocytic maturation/cytodifferentiation was seen in 8/23 patients. Conclusion: Neoadjuvant radiotherapy was effective for myxoid liposarcomas histopathologically, although these histopathological features did not affect the patients' oncological outcomes. Favorable oncological outcomes were obtained with neoadjuvant radiotherapy, surgical resection and chemotherapy. Level of evidence: Level IV, therapeutic study. Keywords: Neoadjuvant radiotherapy, Myxoid liposarcoma, Histopathology, Outcomes |
| format | Article |
| id | doaj-art-1195c26636264da99b24b38f9df9e9ed |
| institution | Matheson Library |
| issn | 1017-995X |
| language | English |
| publishDate | 2017-10-01 |
| publisher | AVES |
| record_format | Article |
| series | Acta Orthopaedica et Traumatologica Turcica |
| spelling | doaj-art-1195c26636264da99b24b38f9df9e9ed2025-07-02T02:09:54ZengAVESActa Orthopaedica et Traumatologica Turcica1017-995X2017-10-01515355361Neoadjuvant radiotherapy for myxoid liposarcomas: Oncologic outcomes and histopathologic correlationsAhmet Salduz0Buğra Alpan1Natig Valiyev2Emre Özmen3Ayça İribaş4Fulya Ağaoğlu5Aysel Bayram6Bilge Bilgiç7Harzem Özger8Istanbul University, Istanbul Medical Faculty, Department of Orthopedics and Traumatology, Turkey; Corresponding author.Department of Orthopedics, Acıbadem Hospital, Maslak, Istanbul, TurkeyDepartment of Orthopedics, Acıbadem Hospital, Maslak, Istanbul, TurkeyIstanbul University, Istanbul Medical Faculty, Department of Radiation Oncology, TurkeyIstanbul University, Istanbul Medical Faculty, Department of Radiation Oncology, TurkeyIstanbul University, Istanbul Medical Faculty, Department of Radiation Oncology, TurkeyIstanbul University, Istanbul Medical Faculty, Department of Pathology, TurkeyIstanbul University, Istanbul Medical Faculty, Department of Pathology, TurkeyIstanbul University, Istanbul Medical Faculty, Department of Orthopedics and Traumatology, TurkeyObjective: The aim of this study was to evaluate the histopathological features of primary extremity myxoid liposarcoma before and after neoadjuvant radiation therapy, and to evaluate the oncological outcomes of the patients. Methods: The study included 23 patients (16 men and 7 women with a mean age of 43 (24–69) years) with primary myxoid liposarcoma of the extremities, who were treated between January 1998 and December 2015. Inclusion criteria were histopathological confirmation of the diagnosis with both the initial biopsy and the resection specimen, and having undergone neoadjuvant radiotherapy. Demographic, clinical and histopathological data were evaluated. Results: Over a mean follow-up time of 55.2 (8–139) months, 5 patients (21.7%) died secondary to disease progression, leaving 18 patients (78.3%) still alive at the time of last follow-up. Only one patient (4%) experienced local recurrence and six (26%) patients developed distant metastases. Disease-free survival at 5 and 10 years were 66%; whereas, overall patient survival at 5 and 10 years were 78.1% and 71.0%, respectively. Tumor size (>15 cm) and presence of metastasis were significantly associated with increased overall mortality. On histopathology, necrosis was present in 12/23 resection specimens. Hyalinization/fibrosis and residual viable tumor was present in all specimens. Adipocytic maturation/cytodifferentiation was seen in 8/23 patients. Conclusion: Neoadjuvant radiotherapy was effective for myxoid liposarcomas histopathologically, although these histopathological features did not affect the patients' oncological outcomes. Favorable oncological outcomes were obtained with neoadjuvant radiotherapy, surgical resection and chemotherapy. Level of evidence: Level IV, therapeutic study. Keywords: Neoadjuvant radiotherapy, Myxoid liposarcoma, Histopathology, Outcomeshttp://www.sciencedirect.com/science/article/pii/S1017995X17301815 |
| spellingShingle | Ahmet Salduz Buğra Alpan Natig Valiyev Emre Özmen Ayça İribaş Fulya Ağaoğlu Aysel Bayram Bilge Bilgiç Harzem Özger Neoadjuvant radiotherapy for myxoid liposarcomas: Oncologic outcomes and histopathologic correlations Acta Orthopaedica et Traumatologica Turcica |
| title | Neoadjuvant radiotherapy for myxoid liposarcomas: Oncologic outcomes and histopathologic correlations |
| title_full | Neoadjuvant radiotherapy for myxoid liposarcomas: Oncologic outcomes and histopathologic correlations |
| title_fullStr | Neoadjuvant radiotherapy for myxoid liposarcomas: Oncologic outcomes and histopathologic correlations |
| title_full_unstemmed | Neoadjuvant radiotherapy for myxoid liposarcomas: Oncologic outcomes and histopathologic correlations |
| title_short | Neoadjuvant radiotherapy for myxoid liposarcomas: Oncologic outcomes and histopathologic correlations |
| title_sort | neoadjuvant radiotherapy for myxoid liposarcomas oncologic outcomes and histopathologic correlations |
| url | http://www.sciencedirect.com/science/article/pii/S1017995X17301815 |
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