COVID-19 vaccine hesitancy and acceptance in patients with multiple myeloma: A national multicenter survey in China
Objective: To investigate factors influencing vaccine hesitancy and its effects on SARS-CoV-2 infection in multiple myeloma (MM) patients during the Omicron BA.4/5 subvariant outbreak. Methods: This cross-sectional study was conducted in mainland China from December 26, 2022, to April 20, 2023. An e...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Asian Pacific Journal of Tropical Medicine |
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| Online Access: | https://journals.lww.com/10.4103/apjtm.apjtm_398_24 |
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| author | Huiwen He Xianghong Jin Ziping Li Shuangjiao Liu Wenming Chen Wanling Sun Baolai Hua Yongzhe Li Junling Zhuang |
| author_facet | Huiwen He Xianghong Jin Ziping Li Shuangjiao Liu Wenming Chen Wanling Sun Baolai Hua Yongzhe Li Junling Zhuang |
| author_sort | Huiwen He |
| collection | DOAJ |
| description | Objective:
To investigate factors influencing vaccine hesitancy and its effects on SARS-CoV-2 infection in multiple myeloma (MM) patients during the Omicron BA.4/5 subvariant outbreak.
Methods:
This cross-sectional study was conducted in mainland China from December 26, 2022, to April 20, 2023. An expert-developed anonymous online questionnaire was distributed via WeChat mini-program to several groups of 500 MM patients, each comprising of 500 patients. The questionnaire covered demographic characteristics, MM medical attributes, COVID-19 vaccine status, and clinical manifestations of COVID-19. Data were analyzed to assess the impact of vaccination on COVID-19 infection rates and the disease severity among MM patients.
Results:
Among 508 valid responses from 30 provinces, only 34.1% (n=173) of MM patients reported receiving COVID-19 vaccination, and the proportions were lower among patients who had undergone autologous stem cell transplantation (20.2% vs. 48.4%, P<0.001). Vaccine hesitancy was primarily attributed to physician recommendations (52.0%), conflicts with MM treatment (37.8%), and concerns about MM progression (31.3%). Hospitalization due to severe SARS-CoV-2 infections was significantly reduced in the vaccinated group (4.8% vs. 12.3%, P=0.038).
Conclusions:
The lower infection rate in MM patients may be attributed to stringent quarantine measures and self-imposed social restrictions. While vaccination did not directly correlate with fewer SARS-CoV-2 infections, it did afford protection to vulnerable populations. Clinicians are encouraged to recommend vaccines to MM patients to mitigate severe infections and associated mortality during recurrent COVID-19 waves. |
| format | Article |
| id | doaj-art-11043d27e86d44d79423d8a43e4b7329 |
| institution | Matheson Library |
| issn | 2352-4146 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj-art-11043d27e86d44d79423d8a43e4b73292025-07-04T06:07:55ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462025-06-0118625326010.4103/apjtm.apjtm_398_24COVID-19 vaccine hesitancy and acceptance in patients with multiple myeloma: A national multicenter survey in ChinaHuiwen HeXianghong JinZiping LiShuangjiao LiuWenming ChenWanling SunBaolai HuaYongzhe LiJunling ZhuangObjective: To investigate factors influencing vaccine hesitancy and its effects on SARS-CoV-2 infection in multiple myeloma (MM) patients during the Omicron BA.4/5 subvariant outbreak. Methods: This cross-sectional study was conducted in mainland China from December 26, 2022, to April 20, 2023. An expert-developed anonymous online questionnaire was distributed via WeChat mini-program to several groups of 500 MM patients, each comprising of 500 patients. The questionnaire covered demographic characteristics, MM medical attributes, COVID-19 vaccine status, and clinical manifestations of COVID-19. Data were analyzed to assess the impact of vaccination on COVID-19 infection rates and the disease severity among MM patients. Results: Among 508 valid responses from 30 provinces, only 34.1% (n=173) of MM patients reported receiving COVID-19 vaccination, and the proportions were lower among patients who had undergone autologous stem cell transplantation (20.2% vs. 48.4%, P<0.001). Vaccine hesitancy was primarily attributed to physician recommendations (52.0%), conflicts with MM treatment (37.8%), and concerns about MM progression (31.3%). Hospitalization due to severe SARS-CoV-2 infections was significantly reduced in the vaccinated group (4.8% vs. 12.3%, P=0.038). Conclusions: The lower infection rate in MM patients may be attributed to stringent quarantine measures and self-imposed social restrictions. While vaccination did not directly correlate with fewer SARS-CoV-2 infections, it did afford protection to vulnerable populations. Clinicians are encouraged to recommend vaccines to MM patients to mitigate severe infections and associated mortality during recurrent COVID-19 waves.https://journals.lww.com/10.4103/apjtm.apjtm_398_24questionnairemultiple myelomavaccinationsars-cov-2outbreak infection |
| spellingShingle | Huiwen He Xianghong Jin Ziping Li Shuangjiao Liu Wenming Chen Wanling Sun Baolai Hua Yongzhe Li Junling Zhuang COVID-19 vaccine hesitancy and acceptance in patients with multiple myeloma: A national multicenter survey in China Asian Pacific Journal of Tropical Medicine questionnaire multiple myeloma vaccination sars-cov-2 outbreak infection |
| title | COVID-19 vaccine hesitancy and acceptance in patients with multiple myeloma: A national multicenter survey in China |
| title_full | COVID-19 vaccine hesitancy and acceptance in patients with multiple myeloma: A national multicenter survey in China |
| title_fullStr | COVID-19 vaccine hesitancy and acceptance in patients with multiple myeloma: A national multicenter survey in China |
| title_full_unstemmed | COVID-19 vaccine hesitancy and acceptance in patients with multiple myeloma: A national multicenter survey in China |
| title_short | COVID-19 vaccine hesitancy and acceptance in patients with multiple myeloma: A national multicenter survey in China |
| title_sort | covid 19 vaccine hesitancy and acceptance in patients with multiple myeloma a national multicenter survey in china |
| topic | questionnaire multiple myeloma vaccination sars-cov-2 outbreak infection |
| url | https://journals.lww.com/10.4103/apjtm.apjtm_398_24 |
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