Loss of p21 does not protect against premature ovarian insufficiency caused by alkylating agents

Loss of p21 does not protect against premature ovarian insufficiency caused by alkylating agents

BackgroundRecent studies have focused on investigating the role of cellular senescence in ovarian aging. Targeting cellular senescence has been proposed as a potential strategy to improve ovarian aging. p16 and p21 are classical molecules involved in mediating cellular senescence. In our previous st...

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Bibliographic Details
Main Authors: Xiaohui Lu, Yongli Han, Jiaming Song, Qin Wan, Pengfei Liu, Li Chen, Yufeng Wang, Pingping Xue, Xiuliang Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Endocrinology
Subjects:
p21
cellular senescence
premature ovarian insufficiency
alkylating agents
defective folliculogenesis
primordial follicle activation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1616965/full
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