Antioxidant and Anti-Inflammatory Effects of Traditional Medicinal Plants for Urolithiasis: A Scoping Review
Urolithiasis (UL) is the presence of stones in the kidneys or urinary tract; its prevalence has increased worldwide. Thus, strategies have been sought to reduce it and one of them is the use of medicinal plants due to their accessibility, low cost, and cultural traditions. Studies on traditional med...
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2025-07-01
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| author | Brenda Pacheco-Hernández Teresa Ayora-Talavera Julia Cano-Sosa Lilia G. Noriega Neith Aracely Pacheco-López Juan M. Vargas-Morales Isabel Medina-Vera Martha Guevara-Cruz Rodolfo Chim-Aké Ana Ligia Gutiérrez-Solis Roberto Lugo Azalia Avila-Nava |
| author_facet | Brenda Pacheco-Hernández Teresa Ayora-Talavera Julia Cano-Sosa Lilia G. Noriega Neith Aracely Pacheco-López Juan M. Vargas-Morales Isabel Medina-Vera Martha Guevara-Cruz Rodolfo Chim-Aké Ana Ligia Gutiérrez-Solis Roberto Lugo Azalia Avila-Nava |
| author_sort | Brenda Pacheco-Hernández |
| collection | DOAJ |
| description | Urolithiasis (UL) is the presence of stones in the kidneys or urinary tract; its prevalence has increased worldwide. Thus, strategies have been sought to reduce it and one of them is the use of medicinal plants due to their accessibility, low cost, and cultural traditions. Studies on traditional medicinal plants in UL mainly documented results of litholytic and urinary parameters. Although, stone formation is related to oxidative stress and inflammation, and only a few studies are focused on these types of biomarkers. Thus, the aim of the present review was to summarize studies showing the antioxidant and anti-inflammatory effects of traditional medicinal plants used in UL management. We performed a scoping review; the database sources used were MEDLINE/PubMed, Google Scholar, SpringerLink, Scielo and Redalyc. From a total of 184 studies screened, six were included from China (2), India (3), and Corea (1). These studies have shown the antioxidant and anti-inflammatory effects of traditional medicinal plants, including <i>Glechoma longituba</i> (<i>G. longituba</i>), <i>Bergenia ligulate</i> (<i>B. ligulate</i>), <i>Lygodium japonicum</i> (<i>L. japonicum</i>), <i>Citrus limon</i> (<i>C. limon</i>), <i>Xanthium strumarium</i> (<i>X. strumarium</i>) and <i>Tribulus terrestris</i> (<i>T. terrestris</i>). They have also described their molecular mechanism of antioxidant and anti-inflammatory effects through the activation of antioxidant genes induced by Nrf2 or by suppressing the inflammatory gene expression by the inhibition of NFκ-B. These effects could be modulated by their bioactive compounds, such as polyphenols, flavonoids, tannins, saponins, and terpenes, present in these plants. This review summarizes the antioxidant and anti-inflammatory effects of traditional medicinal plants and highlights their molecular mechanisms of action and main bioactive compounds. This evidence may be used in biotechnology and synthetic biology areas for the development of new products from plant-derived compounds to reduce the high recurrence rates of UL. |
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| institution | Matheson Library |
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| spelling | doaj-art-0fae9b8e67304e7b81d65cd31e3c3c182025-07-11T14:42:01ZengMDPI AGPlants2223-77472025-07-011413203210.3390/plants14132032Antioxidant and Anti-Inflammatory Effects of Traditional Medicinal Plants for Urolithiasis: A Scoping ReviewBrenda Pacheco-Hernández0Teresa Ayora-Talavera1Julia Cano-Sosa2Lilia G. Noriega3Neith Aracely Pacheco-López4Juan M. Vargas-Morales5Isabel Medina-Vera6Martha Guevara-Cruz7Rodolfo Chim-Aké8Ana Ligia Gutiérrez-Solis9Roberto Lugo10Azalia Avila-Nava11Hospital Regional de Alta Especialidad de la Península de Yucatán, Servicios de Salud del Instituto Mexicano del Seguro Social para el Bienestar (IMSS-BIENESTAR), Mérida 97130, Yucatán, MexicoCentro De Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A. C. Subsede Sureste, Parque Científico Tecnológico de Yucatán, Sierra Papacal-Chuburná Puerto, Mérida 97302, Yucatán, MexicoCentro De Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A. C. Subsede Sureste, Parque Científico Tecnológico de Yucatán, Sierra Papacal-Chuburná Puerto, Mérida 97302, Yucatán, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, MexicoCentro De Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A. C. Subsede Sureste, Parque Científico Tecnológico de Yucatán, Sierra Papacal-Chuburná Puerto, Mérida 97302, Yucatán, MexicoFacultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78300, MexicoDepartamento Metodología de Investigación, Instituto Nacional de Pediatría, Ciudad de México 04530, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, MexicoHospital Regional de Alta Especialidad de la Península de Yucatán, Servicios de Salud del Instituto Mexicano del Seguro Social para el Bienestar (IMSS-BIENESTAR), Mérida 97130, Yucatán, MexicoHospital Regional de Alta Especialidad de la Península de Yucatán, Servicios de Salud del Instituto Mexicano del Seguro Social para el Bienestar (IMSS-BIENESTAR), Mérida 97130, Yucatán, MexicoHospital Regional de Alta Especialidad de la Península de Yucatán, Servicios de Salud del Instituto Mexicano del Seguro Social para el Bienestar (IMSS-BIENESTAR), Mérida 97130, Yucatán, MexicoHospital Regional de Alta Especialidad de la Península de Yucatán, Servicios de Salud del Instituto Mexicano del Seguro Social para el Bienestar (IMSS-BIENESTAR), Mérida 97130, Yucatán, MexicoUrolithiasis (UL) is the presence of stones in the kidneys or urinary tract; its prevalence has increased worldwide. Thus, strategies have been sought to reduce it and one of them is the use of medicinal plants due to their accessibility, low cost, and cultural traditions. Studies on traditional medicinal plants in UL mainly documented results of litholytic and urinary parameters. Although, stone formation is related to oxidative stress and inflammation, and only a few studies are focused on these types of biomarkers. Thus, the aim of the present review was to summarize studies showing the antioxidant and anti-inflammatory effects of traditional medicinal plants used in UL management. We performed a scoping review; the database sources used were MEDLINE/PubMed, Google Scholar, SpringerLink, Scielo and Redalyc. From a total of 184 studies screened, six were included from China (2), India (3), and Corea (1). These studies have shown the antioxidant and anti-inflammatory effects of traditional medicinal plants, including <i>Glechoma longituba</i> (<i>G. longituba</i>), <i>Bergenia ligulate</i> (<i>B. ligulate</i>), <i>Lygodium japonicum</i> (<i>L. japonicum</i>), <i>Citrus limon</i> (<i>C. limon</i>), <i>Xanthium strumarium</i> (<i>X. strumarium</i>) and <i>Tribulus terrestris</i> (<i>T. terrestris</i>). They have also described their molecular mechanism of antioxidant and anti-inflammatory effects through the activation of antioxidant genes induced by Nrf2 or by suppressing the inflammatory gene expression by the inhibition of NFκ-B. These effects could be modulated by their bioactive compounds, such as polyphenols, flavonoids, tannins, saponins, and terpenes, present in these plants. This review summarizes the antioxidant and anti-inflammatory effects of traditional medicinal plants and highlights their molecular mechanisms of action and main bioactive compounds. This evidence may be used in biotechnology and synthetic biology areas for the development of new products from plant-derived compounds to reduce the high recurrence rates of UL.https://www.mdpi.com/2223-7747/14/13/2032kidney stonetraditional medicinebioactive compoundsoxidative stress |
| spellingShingle | Brenda Pacheco-Hernández Teresa Ayora-Talavera Julia Cano-Sosa Lilia G. Noriega Neith Aracely Pacheco-López Juan M. Vargas-Morales Isabel Medina-Vera Martha Guevara-Cruz Rodolfo Chim-Aké Ana Ligia Gutiérrez-Solis Roberto Lugo Azalia Avila-Nava Antioxidant and Anti-Inflammatory Effects of Traditional Medicinal Plants for Urolithiasis: A Scoping Review Plants kidney stone traditional medicine bioactive compounds oxidative stress |
| title | Antioxidant and Anti-Inflammatory Effects of Traditional Medicinal Plants for Urolithiasis: A Scoping Review |
| title_full | Antioxidant and Anti-Inflammatory Effects of Traditional Medicinal Plants for Urolithiasis: A Scoping Review |
| title_fullStr | Antioxidant and Anti-Inflammatory Effects of Traditional Medicinal Plants for Urolithiasis: A Scoping Review |
| title_full_unstemmed | Antioxidant and Anti-Inflammatory Effects of Traditional Medicinal Plants for Urolithiasis: A Scoping Review |
| title_short | Antioxidant and Anti-Inflammatory Effects of Traditional Medicinal Plants for Urolithiasis: A Scoping Review |
| title_sort | antioxidant and anti inflammatory effects of traditional medicinal plants for urolithiasis a scoping review |
| topic | kidney stone traditional medicine bioactive compounds oxidative stress |
| url | https://www.mdpi.com/2223-7747/14/13/2032 |
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