Long-term low-dose atorvastatin therapy and prevention of macroangiopathy complications in elderly patients with Type 2 diabetes mellitus
Aim. To study the effectiveness of long-term low-dose atorvastatin therapy in elderly patients with Type 2 diabetes mellitus (DM-2) and dyslipidemia (DLP). Material and methods. In total, 135 elderly patients with DM-2 and DLP were included in the main group (MG), receiving atorvastatin (10—20 mg/d;...
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«SILICEA-POLIGRAF» LLC
2010-06-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2088 |
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| author | G. A. Batrak S. E. Myasoedova |
| author_facet | G. A. Batrak S. E. Myasoedova |
| author_sort | G. A. Batrak |
| collection | DOAJ |
| description | Aim. To study the effectiveness of long-term low-dose atorvastatin therapy in elderly patients with Type 2 diabetes mellitus (DM-2) and dyslipidemia (DLP). Material and methods. In total, 135 elderly patients with DM-2 and DLP were included in the main group (MG), receiving atorvastatin (10—20 mg/d; mean dose 15,3 mg/d) for 5 years. The control group (CG) included 55 elderly patients with DM-2 and DLP, who received lipid-lowering diet only. Lipid profile and intima-media thickness (IMT) of brachio-cephalic and lower extremity arteries (Duplex scanning) were assessed at baseline and 5 years later. Results. During the five-year follow-up period, MG demonstrated improved lipid profiles, with target lipid levels achieved in 68 % of the patients receiving atorvastatin in the dose of 20 mg/d. Brachio-cephalic IMT was relatively stable (1,23±0,2 mm and 1,22±0,01 mm, respectively, at baseline and 5 years later). In CG, lipid levels remained high, brachio-cephalic IMT increased from 1,25±0,23 mm at baseline to 1,35±0,23 mm 5 years later (p<0,001), and lower extremity IMT increased from 1,21±0,14 mm to 1,45±0,12 mm, respectively (p<0,001). Conclusion. Long-term low-dose atorvastatin therapy improved lipid profile in elderly patients with DM-2 and DLP. Among those receiving atorvastatin in the dose of 20 mg/d, target lipid levels were achieved in 68 %. The therapy also prevented progressing of brachio-cephalic and lower extremity macroangiopathy, was safe and well tolerated. |
| format | Article |
| id | doaj-art-0f95a8ca6df147c1b6f1d331b9a47c24 |
| institution | Matheson Library |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2010-06-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-0f95a8ca6df147c1b6f1d331b9a47c242025-08-04T12:50:15Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252010-06-019368721799Long-term low-dose atorvastatin therapy and prevention of macroangiopathy complications in elderly patients with Type 2 diabetes mellitusG. A. Batrak0S. E. Myasoedova1Ivanovo State Medical Academy. IvanovoIvanovo State Medical Academy. IvanovoAim. To study the effectiveness of long-term low-dose atorvastatin therapy in elderly patients with Type 2 diabetes mellitus (DM-2) and dyslipidemia (DLP). Material and methods. In total, 135 elderly patients with DM-2 and DLP were included in the main group (MG), receiving atorvastatin (10—20 mg/d; mean dose 15,3 mg/d) for 5 years. The control group (CG) included 55 elderly patients with DM-2 and DLP, who received lipid-lowering diet only. Lipid profile and intima-media thickness (IMT) of brachio-cephalic and lower extremity arteries (Duplex scanning) were assessed at baseline and 5 years later. Results. During the five-year follow-up period, MG demonstrated improved lipid profiles, with target lipid levels achieved in 68 % of the patients receiving atorvastatin in the dose of 20 mg/d. Brachio-cephalic IMT was relatively stable (1,23±0,2 mm and 1,22±0,01 mm, respectively, at baseline and 5 years later). In CG, lipid levels remained high, brachio-cephalic IMT increased from 1,25±0,23 mm at baseline to 1,35±0,23 mm 5 years later (p<0,001), and lower extremity IMT increased from 1,21±0,14 mm to 1,45±0,12 mm, respectively (p<0,001). Conclusion. Long-term low-dose atorvastatin therapy improved lipid profile in elderly patients with DM-2 and DLP. Among those receiving atorvastatin in the dose of 20 mg/d, target lipid levels were achieved in 68 %. The therapy also prevented progressing of brachio-cephalic and lower extremity macroangiopathy, was safe and well tolerated.https://cardiovascular.elpub.ru/jour/article/view/2088elderly agediabetes mellitusdyslipidemiaatorvastatin |
| spellingShingle | G. A. Batrak S. E. Myasoedova Long-term low-dose atorvastatin therapy and prevention of macroangiopathy complications in elderly patients with Type 2 diabetes mellitus Кардиоваскулярная терапия и профилактика elderly age diabetes mellitus dyslipidemia atorvastatin |
| title | Long-term low-dose atorvastatin therapy and prevention of macroangiopathy complications in elderly patients with Type 2 diabetes mellitus |
| title_full | Long-term low-dose atorvastatin therapy and prevention of macroangiopathy complications in elderly patients with Type 2 diabetes mellitus |
| title_fullStr | Long-term low-dose atorvastatin therapy and prevention of macroangiopathy complications in elderly patients with Type 2 diabetes mellitus |
| title_full_unstemmed | Long-term low-dose atorvastatin therapy and prevention of macroangiopathy complications in elderly patients with Type 2 diabetes mellitus |
| title_short | Long-term low-dose atorvastatin therapy and prevention of macroangiopathy complications in elderly patients with Type 2 diabetes mellitus |
| title_sort | long term low dose atorvastatin therapy and prevention of macroangiopathy complications in elderly patients with type 2 diabetes mellitus |
| topic | elderly age diabetes mellitus dyslipidemia atorvastatin |
| url | https://cardiovascular.elpub.ru/jour/article/view/2088 |
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