Ferroptosis in central nervous system injuries: molecular mechanisms, diagnostic approaches, and therapeutic strategies

Ferroptosis in central nervous system injuries: molecular mechanisms, diagnostic approaches, and therapeutic strategies

Ferroptosis, an iron-dependent form of cell death, has emerged as a critical factor in the pathogenesis of central nervous system (CNS) injuries, including neurodegenerative diseases, stroke, and traumatic brain injury. This review highlights disrupted iron metabolism, glutathione depletion, and ant...

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Bibliographic Details
Main Authors: Qiuhu Huang, Haowen Zhang, Shenbo Chen, Yao Wang, Jian Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neurological injuries
ferroptosis
iron
lipid peroxidation
central nervous system
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1593963/full
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