Role of Serum Iron in the Activation of Lipid Peroxidation in Critical Conditions
Twenty-four critically ill patients due to generalized purulent peritonitis, pancreatonecrosis, thermal skin injuries, and severe poisoning by acetic acid were examined. The general regularities of the effect of high serum iron concentrations on the health status of patients, on the activity of anti...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2006-06-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1145 |
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| author | Yu. P. Orlov V. T. Dolgikh A. V. Glushchenko T. V. Pritykina A. V. Yershov |
| author_facet | Yu. P. Orlov V. T. Dolgikh A. V. Glushchenko T. V. Pritykina A. V. Yershov |
| author_sort | Yu. P. Orlov |
| collection | DOAJ |
| description | Twenty-four critically ill patients due to generalized purulent peritonitis, pancreatonecrosis, thermal skin injuries, and severe poisoning by acetic acid were examined. The general regularities of the effect of high serum iron concentrations on the health status of patients, on the activity of antioxidative enzymes, and on the initiation of lipid peroxidation (LPO) processes, as supported by the values of Fe2+-induced chemiluminescence, were revealed. In critically ill patients, iron metabolism occurs with the overload of a transport protein, such as transferrin, which is caused by intravascular hemolysis and hemoglobin metabolism to ionized iron. The overload of proteins responsible for iron transport leads to the tissue accumulation of free (ferrous and ferric) iron that is actively involved in the processes of LPO initiation with excess synthesis of cytotoxic radicals, which in turn accounts for the severity of endotoxicosis. |
| format | Article |
| id | doaj-art-0eb32b4e1ac74bb7af49e01e1ebe42b0 |
| institution | Matheson Library |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2006-06-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-0eb32b4e1ac74bb7af49e01e1ebe42b02025-08-04T10:40:36ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102006-06-0123182210.15360/1813-9779-2006-3-18-221145Role of Serum Iron in the Activation of Lipid Peroxidation in Critical ConditionsYu. P. Orlov0V. T. Dolgikh1A. V. Glushchenko2T. V. Pritykina3A. V. Yershov4Omsk State Medical Academy, City Emergency Health Care Hospital One, OmskOmsk State Medical Academy, City Emergency Health Care Hospital One, OmskOmsk State Medical Academy, City Emergency Health Care Hospital One, OmskOmsk State Medical Academy, City Emergency Health Care Hospital One, OmskOmsk State Medical Academy, City Emergency Health Care Hospital One, OmskTwenty-four critically ill patients due to generalized purulent peritonitis, pancreatonecrosis, thermal skin injuries, and severe poisoning by acetic acid were examined. The general regularities of the effect of high serum iron concentrations on the health status of patients, on the activity of antioxidative enzymes, and on the initiation of lipid peroxidation (LPO) processes, as supported by the values of Fe2+-induced chemiluminescence, were revealed. In critically ill patients, iron metabolism occurs with the overload of a transport protein, such as transferrin, which is caused by intravascular hemolysis and hemoglobin metabolism to ionized iron. The overload of proteins responsible for iron transport leads to the tissue accumulation of free (ferrous and ferric) iron that is actively involved in the processes of LPO initiation with excess synthesis of cytotoxic radicals, which in turn accounts for the severity of endotoxicosis.https://www.reanimatology.com/rmt/article/view/1145serum ironiron ionsfree radical oxidationantioxidantsendotoxicosis |
| spellingShingle | Yu. P. Orlov V. T. Dolgikh A. V. Glushchenko T. V. Pritykina A. V. Yershov Role of Serum Iron in the Activation of Lipid Peroxidation in Critical Conditions Общая реаниматология serum iron iron ions free radical oxidation antioxidants endotoxicosis |
| title | Role of Serum Iron in the Activation of Lipid Peroxidation in Critical Conditions |
| title_full | Role of Serum Iron in the Activation of Lipid Peroxidation in Critical Conditions |
| title_fullStr | Role of Serum Iron in the Activation of Lipid Peroxidation in Critical Conditions |
| title_full_unstemmed | Role of Serum Iron in the Activation of Lipid Peroxidation in Critical Conditions |
| title_short | Role of Serum Iron in the Activation of Lipid Peroxidation in Critical Conditions |
| title_sort | role of serum iron in the activation of lipid peroxidation in critical conditions |
| topic | serum iron iron ions free radical oxidation antioxidants endotoxicosis |
| url | https://www.reanimatology.com/rmt/article/view/1145 |
| work_keys_str_mv | AT yuporlov roleofserumironintheactivationoflipidperoxidationincriticalconditions AT vtdolgikh roleofserumironintheactivationoflipidperoxidationincriticalconditions AT avglushchenko roleofserumironintheactivationoflipidperoxidationincriticalconditions AT tvpritykina roleofserumironintheactivationoflipidperoxidationincriticalconditions AT avyershov roleofserumironintheactivationoflipidperoxidationincriticalconditions |