Swine Flu Progressive Pulmonary Fibrosis – Clinical Manifestation and Morphology of Explanted Lungs

Novel influenza A (H1N1) virus also known as swine flu results from the combination of genetic elements from swine, human, and avian viruses. During the 2009 swine flu pandemic, millions of people got infected with swine flu. Between April 2009 and April 2010, a large number of deaths were reported....

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Main Authors: Shirish Sahebrao Chandanwale, Madhuri Singh, Akshi Raj, Charusheela Gore, Namit Gupta
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-04-01
Series:Indian Journal of Transplantation
Subjects:
Online Access:https://journals.lww.com/10.4103/ijot.ijot_125_24
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author Shirish Sahebrao Chandanwale
Madhuri Singh
Akshi Raj
Charusheela Gore
Namit Gupta
author_facet Shirish Sahebrao Chandanwale
Madhuri Singh
Akshi Raj
Charusheela Gore
Namit Gupta
author_sort Shirish Sahebrao Chandanwale
collection DOAJ
description Novel influenza A (H1N1) virus also known as swine flu results from the combination of genetic elements from swine, human, and avian viruses. During the 2009 swine flu pandemic, millions of people got infected with swine flu. Between April 2009 and April 2010, a large number of deaths were reported. The virus is antigenetically distinct from seasonal influenza infection and is usually sensitive to oseltamivir. In recent years, sporadic cases of swine flu have been reported globally. There has been spurt in swine flu cases in India in recent years. Although a large number of swine flu patients present with acute respiratory distress syndrome, majority of these patients show complete recovery without leaving any residual illness. Few cases show residual fibrosis on high-resolution computed tomography after recovery. Even with high degree suspicion, clinical diagnosis is difficult. Confirmatory laboratory tests are essential for definitive diagnosis. We report a case of a 54-year-old female without any comorbidities who developed progressive pulmonary fibrosis and she required bilateral lung transplant.
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publisher Wolters Kluwer Medknow Publications
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series Indian Journal of Transplantation
spelling doaj-art-0c8e36ece4e64869be543e1e033ee1042025-07-04T07:39:49ZengWolters Kluwer Medknow PublicationsIndian Journal of Transplantation2212-00172212-00252025-04-0119224324610.4103/ijot.ijot_125_24Swine Flu Progressive Pulmonary Fibrosis – Clinical Manifestation and Morphology of Explanted LungsShirish Sahebrao ChandanwaleMadhuri SinghAkshi RajCharusheela GoreNamit GuptaNovel influenza A (H1N1) virus also known as swine flu results from the combination of genetic elements from swine, human, and avian viruses. During the 2009 swine flu pandemic, millions of people got infected with swine flu. Between April 2009 and April 2010, a large number of deaths were reported. The virus is antigenetically distinct from seasonal influenza infection and is usually sensitive to oseltamivir. In recent years, sporadic cases of swine flu have been reported globally. There has been spurt in swine flu cases in India in recent years. Although a large number of swine flu patients present with acute respiratory distress syndrome, majority of these patients show complete recovery without leaving any residual illness. Few cases show residual fibrosis on high-resolution computed tomography after recovery. Even with high degree suspicion, clinical diagnosis is difficult. Confirmatory laboratory tests are essential for definitive diagnosis. We report a case of a 54-year-old female without any comorbidities who developed progressive pulmonary fibrosis and she required bilateral lung transplant.https://journals.lww.com/10.4103/ijot.ijot_125_24fibrosislungsprogressiveswine flutransplant
spellingShingle Shirish Sahebrao Chandanwale
Madhuri Singh
Akshi Raj
Charusheela Gore
Namit Gupta
Swine Flu Progressive Pulmonary Fibrosis – Clinical Manifestation and Morphology of Explanted Lungs
Indian Journal of Transplantation
fibrosis
lungs
progressive
swine flu
transplant
title Swine Flu Progressive Pulmonary Fibrosis – Clinical Manifestation and Morphology of Explanted Lungs
title_full Swine Flu Progressive Pulmonary Fibrosis – Clinical Manifestation and Morphology of Explanted Lungs
title_fullStr Swine Flu Progressive Pulmonary Fibrosis – Clinical Manifestation and Morphology of Explanted Lungs
title_full_unstemmed Swine Flu Progressive Pulmonary Fibrosis – Clinical Manifestation and Morphology of Explanted Lungs
title_short Swine Flu Progressive Pulmonary Fibrosis – Clinical Manifestation and Morphology of Explanted Lungs
title_sort swine flu progressive pulmonary fibrosis clinical manifestation and morphology of explanted lungs
topic fibrosis
lungs
progressive
swine flu
transplant
url https://journals.lww.com/10.4103/ijot.ijot_125_24
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