Inflammation markers in atherosclerosis development
Aim. To study different inflammation markers at various stages of atherosclerosis progression.Material and methods. In 174 21-70-year-old people, brachial artery ultrasound (Aloka 5000) was performed to visualize atherosclerotic plaques and assess intima-media thickness (IMT). Immuno-enzyme analysis...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2009-06-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1422 |
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| Summary: | Aim. To study different inflammation markers at various stages of atherosclerosis progression.Material and methods. In 174 21-70-year-old people, brachial artery ultrasound (Aloka 5000) was performed to visualize atherosclerotic plaques and assess intima-media thickness (IMT). Immuno-enzyme analysis was used to measure plasma levels of C-reactive protein, CRP (SeroELISA test system, Diagnostic Systems Laboratories, USA), and cytokines — tumor necrosis factor alpha (THF-alpha), interleukins 1, 4 and 8 (IL-1, 2, and 8) (Russian test systems, Cytokine company, St. Petersburg).Results. The levels of CRP, IL-1, IL-8 and TNF-alpha were dependent on atherosclerotic process stage and IMT CRP levels typical for systemic inflammatory reaction were observed in individuals with subclinical atherosclerosis and patients with post-infarction cardiosclerosis.Conclusion. There was an association between IMT and latent inflammation activity. Qualitative changes in inflammation intensity were observed even at early stages of atherosclerosis development. |
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| ISSN: | 1728-8800 2619-0125 |