Possibilities of Therapeutic Angiogenesis in Patients with Critical Lower Limb Ischemia
Two clinical observations of effective treatment of patients with critical ischemia of the lower extremities using plasma-free lysate autologous platelets. Both patients were male, 73 and 53 years old. Both were diagnosed with total damage to the arteries of the infrainguinal zone. One of them had p...
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Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
2024-01-01
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| Series: | Неотложная медицинская помощь |
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| Online Access: | https://www.jnmp.ru/jour/article/view/1732 |
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| author | I. P. Mikhailov N. V. Borovkova B. V. Kozlovsky I. N. Ponomarev N. Ye. Kudryashova O. V. Leshchinskaya |
| author_facet | I. P. Mikhailov N. V. Borovkova B. V. Kozlovsky I. N. Ponomarev N. Ye. Kudryashova O. V. Leshchinskaya |
| author_sort | I. P. Mikhailov |
| collection | DOAJ |
| description | Two clinical observations of effective treatment of patients with critical ischemia of the lower extremities using plasma-free lysate autologous platelets. Both patients were male, 73 and 53 years old. Both were diagnosed with total damage to the arteries of the infrainguinal zone. One of them had previously undergone endarterectomy from the femoral artery with subsequent thrombosis. After examination and joint discussion with x-ray endovascular surgeons, they were found inoperable. Due to the ineffectiveness of standard conservative therapy, the patient was offered local administration of plasma-free lysate autologous platelets. After receiving written informed consent, the procedure for collecting venous blood and obtaining plasma-free lysate autologous platelets and the introduction of this drug into the muscles of the leg from the side of ischemia according to the original method. The method for assessing microcirculation was three-phase scintigraphy : before treatment, both patients showed a significant decrease in the inclusion of osteotropic radiopharmaceutical in the soft tissues of the legs. For areas of radiopharmaceutical hyperfixation, relative accumulation coefficients were calculated: for one patient, the calculation results demonstrated the formation of foci of aseptic necrosis. When patients were re-hospitalized after 6 months, there was an improvement in local status and relief of rest pain. According to scintigraphy, a significant improvement in microcirculation was noted; no foci of aseptic necrosis were identified. Thus, the use of plasma-free lysate autologous platelets in combination with complex conservative therapy has demonstrated positive results; this method can be considered as an alternative revascularization ischemic limb. |
| format | Article |
| id | doaj-art-0c4f1f2e68f74dac8b4fe57702bcfa72 |
| institution | Matheson Library |
| issn | 2223-9022 2541-8017 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department |
| record_format | Article |
| series | Неотложная медицинская помощь |
| spelling | doaj-art-0c4f1f2e68f74dac8b4fe57702bcfa722025-08-04T10:30:25ZrusSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentНеотложная медицинская помощь2223-90222541-80172024-01-0112467668210.23934/2223-9022-2023-12-4-676-682906Possibilities of Therapeutic Angiogenesis in Patients with Critical Lower Limb IschemiaI. P. Mikhailov0N. V. Borovkova1B. V. Kozlovsky2I. N. Ponomarev3N. Ye. Kudryashova4O. V. Leshchinskaya5N.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineTwo clinical observations of effective treatment of patients with critical ischemia of the lower extremities using plasma-free lysate autologous platelets. Both patients were male, 73 and 53 years old. Both were diagnosed with total damage to the arteries of the infrainguinal zone. One of them had previously undergone endarterectomy from the femoral artery with subsequent thrombosis. After examination and joint discussion with x-ray endovascular surgeons, they were found inoperable. Due to the ineffectiveness of standard conservative therapy, the patient was offered local administration of plasma-free lysate autologous platelets. After receiving written informed consent, the procedure for collecting venous blood and obtaining plasma-free lysate autologous platelets and the introduction of this drug into the muscles of the leg from the side of ischemia according to the original method. The method for assessing microcirculation was three-phase scintigraphy : before treatment, both patients showed a significant decrease in the inclusion of osteotropic radiopharmaceutical in the soft tissues of the legs. For areas of radiopharmaceutical hyperfixation, relative accumulation coefficients were calculated: for one patient, the calculation results demonstrated the formation of foci of aseptic necrosis. When patients were re-hospitalized after 6 months, there was an improvement in local status and relief of rest pain. According to scintigraphy, a significant improvement in microcirculation was noted; no foci of aseptic necrosis were identified. Thus, the use of plasma-free lysate autologous platelets in combination with complex conservative therapy has demonstrated positive results; this method can be considered as an alternative revascularization ischemic limb.https://www.jnmp.ru/jour/article/view/1732critical ischemia of the lower extremitiestherapeutic angiogenesisplasma-free lysate autologous plateletsconservative therapytriphasic scintigraphy |
| spellingShingle | I. P. Mikhailov N. V. Borovkova B. V. Kozlovsky I. N. Ponomarev N. Ye. Kudryashova O. V. Leshchinskaya Possibilities of Therapeutic Angiogenesis in Patients with Critical Lower Limb Ischemia Неотложная медицинская помощь critical ischemia of the lower extremities therapeutic angiogenesis plasma-free lysate autologous platelets conservative therapy triphasic scintigraphy |
| title | Possibilities of Therapeutic Angiogenesis in Patients with Critical Lower Limb Ischemia |
| title_full | Possibilities of Therapeutic Angiogenesis in Patients with Critical Lower Limb Ischemia |
| title_fullStr | Possibilities of Therapeutic Angiogenesis in Patients with Critical Lower Limb Ischemia |
| title_full_unstemmed | Possibilities of Therapeutic Angiogenesis in Patients with Critical Lower Limb Ischemia |
| title_short | Possibilities of Therapeutic Angiogenesis in Patients with Critical Lower Limb Ischemia |
| title_sort | possibilities of therapeutic angiogenesis in patients with critical lower limb ischemia |
| topic | critical ischemia of the lower extremities therapeutic angiogenesis plasma-free lysate autologous platelets conservative therapy triphasic scintigraphy |
| url | https://www.jnmp.ru/jour/article/view/1732 |
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