Spectrophotometric Determination of Lisinopril Drug by Oxidative Coupling Reaction with 4-aminonaphthalene-1- sulfonic acid Reagent
A simple, rapid and sensitive spectrophotometric method for determination of Lisinopril (LS) in both pure form and pharmaceutical preparations has been reported. The adapted technique based on utilization 4-aminonaphthalene-1-sulfonic acid as a Chromogenic reagent through an oxidative coupling reac...
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Tikrit University
2022-12-01
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| Series: | Tikrit Journal of Pure Science |
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| Online Access: | https://tjpsj.org/index.php/tjps/article/view/98 |
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| author | Abdul Majeed Khorsheed Ahmed Nashwan Omar Tapabashi Noor Mansoor Ghaib Allah |
| author_facet | Abdul Majeed Khorsheed Ahmed Nashwan Omar Tapabashi Noor Mansoor Ghaib Allah |
| author_sort | Abdul Majeed Khorsheed Ahmed |
| collection | DOAJ |
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A simple, rapid and sensitive spectrophotometric method for determination of Lisinopril (LS) in both pure form and pharmaceutical preparations has been reported. The adapted technique based on utilization 4-aminonaphthalene-1-sulfonic acid as a Chromogenic reagent through an oxidative coupling reaction with Lisinopril and Potassium Peroxydisulfate (oxidation agent) in acidic medium to form green dye soluble product absorption maxima at 612 nm. Linearity was in the range 2–43 μg ml-1. The values of molar absorption coefficient (ε), correlation coefficient and Sandel’s index were found to be 10.3808 × 103 L. mole-1 cm-1, 0.9995 and 0.00343 µg.cm-2 respectively. The average of recovery % was 100.067. Detection Limit and quantitative limit were 0.0343 µg/ml and 0.1143 µg/ml. The proposed method has been successfully applied in the determination of preparations containing lisinopril.
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| format | Article |
| id | doaj-art-0c49e57e9e7b4c9da630d4e730d89ea0 |
| institution | Matheson Library |
| issn | 1813-1662 2415-1726 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Tikrit University |
| record_format | Article |
| series | Tikrit Journal of Pure Science |
| spelling | doaj-art-0c49e57e9e7b4c9da630d4e730d89ea02025-07-12T09:59:14ZengTikrit UniversityTikrit Journal of Pure Science1813-16622415-17262022-12-0126110.25130/tjps.v26i1.98Spectrophotometric Determination of Lisinopril Drug by Oxidative Coupling Reaction with 4-aminonaphthalene-1- sulfonic acid ReagentAbdul Majeed Khorsheed AhmedNashwan Omar TapabashiNoor Mansoor Ghaib Allah A simple, rapid and sensitive spectrophotometric method for determination of Lisinopril (LS) in both pure form and pharmaceutical preparations has been reported. The adapted technique based on utilization 4-aminonaphthalene-1-sulfonic acid as a Chromogenic reagent through an oxidative coupling reaction with Lisinopril and Potassium Peroxydisulfate (oxidation agent) in acidic medium to form green dye soluble product absorption maxima at 612 nm. Linearity was in the range 2–43 μg ml-1. The values of molar absorption coefficient (ε), correlation coefficient and Sandel’s index were found to be 10.3808 × 103 L. mole-1 cm-1, 0.9995 and 0.00343 µg.cm-2 respectively. The average of recovery % was 100.067. Detection Limit and quantitative limit were 0.0343 µg/ml and 0.1143 µg/ml. The proposed method has been successfully applied in the determination of preparations containing lisinopril. https://tjpsj.org/index.php/tjps/article/view/98SpectrophotometricPharmaceuticalLisinoprilOxidative Coupling |
| spellingShingle | Abdul Majeed Khorsheed Ahmed Nashwan Omar Tapabashi Noor Mansoor Ghaib Allah Spectrophotometric Determination of Lisinopril Drug by Oxidative Coupling Reaction with 4-aminonaphthalene-1- sulfonic acid Reagent Tikrit Journal of Pure Science Spectrophotometric Pharmaceutical Lisinopril Oxidative Coupling |
| title | Spectrophotometric Determination of Lisinopril Drug by Oxidative Coupling Reaction with 4-aminonaphthalene-1- sulfonic acid Reagent |
| title_full | Spectrophotometric Determination of Lisinopril Drug by Oxidative Coupling Reaction with 4-aminonaphthalene-1- sulfonic acid Reagent |
| title_fullStr | Spectrophotometric Determination of Lisinopril Drug by Oxidative Coupling Reaction with 4-aminonaphthalene-1- sulfonic acid Reagent |
| title_full_unstemmed | Spectrophotometric Determination of Lisinopril Drug by Oxidative Coupling Reaction with 4-aminonaphthalene-1- sulfonic acid Reagent |
| title_short | Spectrophotometric Determination of Lisinopril Drug by Oxidative Coupling Reaction with 4-aminonaphthalene-1- sulfonic acid Reagent |
| title_sort | spectrophotometric determination of lisinopril drug by oxidative coupling reaction with 4 aminonaphthalene 1 sulfonic acid reagent |
| topic | Spectrophotometric Pharmaceutical Lisinopril Oxidative Coupling |
| url | https://tjpsj.org/index.php/tjps/article/view/98 |
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