Correlation of TPO Antibody Concentration with Thyroid Hormones as a Predictor of Clinical Hypothyroidism
This study aimed to determine the relationship between the concentration of thyroid peroxidase antibodies (TPO-Ab) and thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) in patients with chronic lymphocytic thyroiditis. This cross-sectional study included 144...
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Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2024-01-01
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Series: | Acta Clinica Croatica |
Subjects: | |
Online Access: | https://hrcak.srce.hr/file/481946 |
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Summary: | This study aimed to determine the relationship between the concentration of thyroid
peroxidase antibodies (TPO-Ab) and thyroid-stimulating hormone (TSH), free thyroxine (FT4), and
free triiodothyronine (FT3) in patients with chronic lymphocytic thyroiditis. This cross-sectional study
included 144 patients diagnosed with chronic lymphocytic thyroiditis whose mean age was 46±15 years
at the time of diagnosis. According to their TSH concentration, the patients were either euthyroid or
hypothyroid. After 59 patients were excluded due to TSH levels below the reference range, no TPO-Ab
findings, substitution therapy, immune hyperthyroidism, or TPO-Ab and TSH levels outside the resolution
limits of the laboratory tests, 85 patients remained in the study. A positive correlation was found
between TPO-Ab and TSH concentration within the euthyroid and hypothyroid range and a negative
correlation between TPO-Ab and FT4 concentration. The result suggests that the TSH and TPO-Ab
concentration could be used to identify individuals at risk for the development of hypothyroidism in the
general population. |
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ISSN: | 0353-9466 1333-9451 |