Yunnan Baiyao (YNBY): pharmacological mechanisms, therapeutic applications, and clinical evidence
Yunnan Baiyao (YNBY) is a traditional Chinese medicine widely used in hemostasis, anti-inflammation, antibacterial, analgesia and wound healing. This article reviews the research progress on the pharmacological mechanism, clinical application and safety of YNBY in the past two decades. Through syste...
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| Format: | Article |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1589035/full |
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| author | Hongjing Qian Hongjing Qian Wanli Zhang Wanli Zhang Mingzhu Zhang Mingzhu Zhang Sijia Ma Sijia Ma Manhong Zhen Manhong Zhen Hongbing He Hongbing He Xiaobin Ren Xiaobin Ren |
| author_facet | Hongjing Qian Hongjing Qian Wanli Zhang Wanli Zhang Mingzhu Zhang Mingzhu Zhang Sijia Ma Sijia Ma Manhong Zhen Manhong Zhen Hongbing He Hongbing He Xiaobin Ren Xiaobin Ren |
| author_sort | Hongjing Qian |
| collection | DOAJ |
| description | Yunnan Baiyao (YNBY) is a traditional Chinese medicine widely used in hemostasis, anti-inflammation, antibacterial, analgesia and wound healing. This article reviews the research progress on the pharmacological mechanism, clinical application and safety of YNBY in the past two decades. Through systematic analysis of clinical trials, animal experiments and mechanistic studies, YNBY has shown significant effects in reducing surgical bleeding (such as reducing blood loss in orthognathic surgery by 21.4%), accelerating wound healing (such as increasing the healing rate of diabetic ulcers by 37%), regulating inflammation (such as inhibiting the expression of IL-6/CRP in arthritis), and inhibiting bacterial virulence (such as destroying Staphylococcus aureus biofilm). Mechanistic studies have shown that YNBY acts through multiple pathways, including platelet activation, arachidonic acid metabolism regulation and autophagy regulation. However, existing studies have limitations such as inconsistent trial design and insufficient long-term safety data. This study provides a theoretical basis for optimizing the clinical application of YNBY, and points out future research directions, including the identification of active ingredients, the development of targeted delivery systems, and the development of large-scale randomized controlled trials. |
| format | Article |
| id | doaj-art-0c1cda9b46f2488cae7e53eb8be679c1 |
| institution | Matheson Library |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-0c1cda9b46f2488cae7e53eb8be679c12025-07-09T13:22:48ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.15890351589035Yunnan Baiyao (YNBY): pharmacological mechanisms, therapeutic applications, and clinical evidenceHongjing Qian0Hongjing Qian1Wanli Zhang2Wanli Zhang3Mingzhu Zhang4Mingzhu Zhang5Sijia Ma6Sijia Ma7Manhong Zhen8Manhong Zhen9Hongbing He10Hongbing He11Xiaobin Ren12Xiaobin Ren13Yunnan Key Laboratory of Stomatology, School of Stomatology, Kunming Medical University, Kunming, ChinaDepartment of Periodontology, Kunming Medical University School and Hospital of Stomatology, Kunming Medical University, Kunming, ChinaYunnan Key Laboratory of Stomatology, School of Stomatology, Kunming Medical University, Kunming, ChinaDepartment of Periodontology, Kunming Medical University School and Hospital of Stomatology, Kunming Medical University, Kunming, ChinaYunnan Key Laboratory of Stomatology, School of Stomatology, Kunming Medical University, Kunming, ChinaDepartment of Periodontology, Kunming Medical University School and Hospital of Stomatology, Kunming Medical University, Kunming, ChinaYunnan Key Laboratory of Stomatology, School of Stomatology, Kunming Medical University, Kunming, ChinaDepartment of Periodontology, Kunming Medical University School and Hospital of Stomatology, Kunming Medical University, Kunming, ChinaYunnan Key Laboratory of Stomatology, School of Stomatology, Kunming Medical University, Kunming, ChinaDepartment of Periodontology, Kunming Medical University School and Hospital of Stomatology, Kunming Medical University, Kunming, ChinaYunnan Key Laboratory of Stomatology, School of Stomatology, Kunming Medical University, Kunming, ChinaDepartment of Periodontology, Kunming Medical University School and Hospital of Stomatology, Kunming Medical University, Kunming, ChinaYunnan Key Laboratory of Stomatology, School of Stomatology, Kunming Medical University, Kunming, ChinaDepartment of Periodontology, Kunming Medical University School and Hospital of Stomatology, Kunming Medical University, Kunming, ChinaYunnan Baiyao (YNBY) is a traditional Chinese medicine widely used in hemostasis, anti-inflammation, antibacterial, analgesia and wound healing. This article reviews the research progress on the pharmacological mechanism, clinical application and safety of YNBY in the past two decades. Through systematic analysis of clinical trials, animal experiments and mechanistic studies, YNBY has shown significant effects in reducing surgical bleeding (such as reducing blood loss in orthognathic surgery by 21.4%), accelerating wound healing (such as increasing the healing rate of diabetic ulcers by 37%), regulating inflammation (such as inhibiting the expression of IL-6/CRP in arthritis), and inhibiting bacterial virulence (such as destroying Staphylococcus aureus biofilm). Mechanistic studies have shown that YNBY acts through multiple pathways, including platelet activation, arachidonic acid metabolism regulation and autophagy regulation. However, existing studies have limitations such as inconsistent trial design and insufficient long-term safety data. This study provides a theoretical basis for optimizing the clinical application of YNBY, and points out future research directions, including the identification of active ingredients, the development of targeted delivery systems, and the development of large-scale randomized controlled trials.https://www.frontiersin.org/articles/10.3389/fphar.2025.1589035/fullYunnan Baiyaobotanical drugclinical applicationhemostatic efficacytraditional Chinese medicine |
| spellingShingle | Hongjing Qian Hongjing Qian Wanli Zhang Wanli Zhang Mingzhu Zhang Mingzhu Zhang Sijia Ma Sijia Ma Manhong Zhen Manhong Zhen Hongbing He Hongbing He Xiaobin Ren Xiaobin Ren Yunnan Baiyao (YNBY): pharmacological mechanisms, therapeutic applications, and clinical evidence Frontiers in Pharmacology Yunnan Baiyao botanical drug clinical application hemostatic efficacy traditional Chinese medicine |
| title | Yunnan Baiyao (YNBY): pharmacological mechanisms, therapeutic applications, and clinical evidence |
| title_full | Yunnan Baiyao (YNBY): pharmacological mechanisms, therapeutic applications, and clinical evidence |
| title_fullStr | Yunnan Baiyao (YNBY): pharmacological mechanisms, therapeutic applications, and clinical evidence |
| title_full_unstemmed | Yunnan Baiyao (YNBY): pharmacological mechanisms, therapeutic applications, and clinical evidence |
| title_short | Yunnan Baiyao (YNBY): pharmacological mechanisms, therapeutic applications, and clinical evidence |
| title_sort | yunnan baiyao ynby pharmacological mechanisms therapeutic applications and clinical evidence |
| topic | Yunnan Baiyao botanical drug clinical application hemostatic efficacy traditional Chinese medicine |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1589035/full |
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