The antiarrhythmic activity comparative study of Lappaconitine hydrobromide and LMG-124 on the model of aconitine arrhythmia
Two models of the aconitin-induced cardiac arrhythmias were used to compare the antiarrhythmic and antifibrillatory activity of the reference drug Lappaconitine hydrobromide and the LMG-124 compound. It is shown that both compounds have antiarrhythmic action. At the same time, the compound LMG-124 r...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC “Publisher OKI”
2017-03-01
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| Series: | Фармакокинетика и Фармакодинамика |
| Subjects: | |
| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/12 |
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| Summary: | Two models of the aconitin-induced cardiac arrhythmias were used to compare the antiarrhythmic and antifibrillatory activity of the reference drug Lappaconitine hydrobromide and the LMG-124 compound. It is shown that both compounds have antiarrhythmic action. At the same time, the compound LMG-124 realizes its antiarrhythmic effect in a significantly lower dose. In this case, the compound LMG-124 shows a pronounced antifibrillatory activity, in contrast to the reference drug Lappaconitine hydrobromide, which in the studied dose does not exhibit similar activity. |
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| ISSN: | 2587-7836 2686-8830 |