Repeat modules and N-linked glycans define structure and antigenicity of a critical enterotoxigenic E. coli adhesin.

Repeat modules and N-linked glycans define structure and antigenicity of a critical enterotoxigenic E. coli adhesin.

Enterotoxigenic Escherichia coli (ETEC) cause hundreds of millions of cases of infectious diarrhea annually, predominantly in children from low-middle income regions. Notably, in children, as well as volunteers challenged with ETEC, diarrheal severity is significantly increased in blood group A (bgA...

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Main Authors: Zachary T Berndsen, Marjahan Akhtar, Mahima Thapa, Tim J Vickers, Aaron Schmitz, Jonathan L Torres, Sabyasachi Baboo, Pardeep Kumar, Nazia Khatoon, Alaullah Sheikh, Melissa Hamrick, Jolene K Diedrich, Salvador Martinez-Bartolome, Patrick T Garrett, John R Yates, Jackson S Turner, Renee M Laird, Frédéric Poly, Chad K Porter, Jeffrey Copps, Ali H Ellebedy, Andrew B Ward, James M Fleckenstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012241
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