EFFECTIVENESS OF NEW SKIN TEST (DIASKINTEST) IN REVELATION OF INFECTED ADOLESCENTS WHO HAD A CONTACT WITH PATIENTS WITH TUBERCULOSIS
Skin tuberculin Mantoux test is widely used for the revelation of latent tuberculosis infection (LTI). Low specificity of the test (high rate of false-positive reactions due to the cross-sensitizing to vaccine strain Mycobacterium bovis BCG) results in difficulties in its interpretation. New method...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2011-05-01
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| Series: | Вопросы современной педиатрии |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/615 |
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| author | L.V. Slogotskaya Ya.A. Kochetkov O.Yu. Senchikhina |
| author_facet | L.V. Slogotskaya Ya.A. Kochetkov O.Yu. Senchikhina |
| author_sort | L.V. Slogotskaya |
| collection | DOAJ |
| description | Skin tuberculin Mantoux test is widely used for the revelation of latent tuberculosis infection (LTI). Low specificity of the test (high rate of false-positive reactions due to the cross-sensitizing to vaccine strain Mycobacterium bovis BCG) results in difficulties in its interpretation. New method of LTI and active tuberculosis diagnostics is Diaskintest; it contains proteins CFP 10 and ESAT 6 which are absent in genome of M. bovis BCG and in most non-tuberculosis mycobacteria. The article presents results of a study of diagnostical value of Diaskintest (0.2 mkg/0.1 ml) and Mantoux test (with 2 TU PPD-L) in adolescents who had contacted with patients with tuberculosis. 143 adolescents from 2 colleges were examined, Diaskintest was performed in all of them, Mantoux test — in 131 patients, X-ray imaging including computer tomography — in all patients. Diaskintest demonstrated high sensitivity and specificity in diagnostics of tuberculosis in adolescents who had a contact with infected persons. 77.9% had positive Mantoux test (102/131), 5.6% — positive Diaskintest (8/143). Diaskintest revealed 5 cases of tuberculosis and 3 cases of LTI.Key words: adolescents, tuberculosis, Mantoux test, Diaskintest, diagnostics.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (3): 70–75) |
| format | Article |
| id | doaj-art-0b6438ed5e13479f8dc467d3ebc29a9c |
| institution | Matheson Library |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2011-05-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-0b6438ed5e13479f8dc467d3ebc29a9c2025-08-04T13:09:26Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352011-05-01103615EFFECTIVENESS OF NEW SKIN TEST (DIASKINTEST) IN REVELATION OF INFECTED ADOLESCENTS WHO HAD A CONTACT WITH PATIENTS WITH TUBERCULOSISL.V. Slogotskaya0Ya.A. Kochetkov1O.Yu. Senchikhina2Moscow City Scientific-Practical Center of Tuberculosis ControlMoscow City Scientific-Practical Center of Tuberculosis ControlAnti-Tuberculosis Clinic № 18, MoscowSkin tuberculin Mantoux test is widely used for the revelation of latent tuberculosis infection (LTI). Low specificity of the test (high rate of false-positive reactions due to the cross-sensitizing to vaccine strain Mycobacterium bovis BCG) results in difficulties in its interpretation. New method of LTI and active tuberculosis diagnostics is Diaskintest; it contains proteins CFP 10 and ESAT 6 which are absent in genome of M. bovis BCG and in most non-tuberculosis mycobacteria. The article presents results of a study of diagnostical value of Diaskintest (0.2 mkg/0.1 ml) and Mantoux test (with 2 TU PPD-L) in adolescents who had contacted with patients with tuberculosis. 143 adolescents from 2 colleges were examined, Diaskintest was performed in all of them, Mantoux test — in 131 patients, X-ray imaging including computer tomography — in all patients. Diaskintest demonstrated high sensitivity and specificity in diagnostics of tuberculosis in adolescents who had a contact with infected persons. 77.9% had positive Mantoux test (102/131), 5.6% — positive Diaskintest (8/143). Diaskintest revealed 5 cases of tuberculosis and 3 cases of LTI.Key words: adolescents, tuberculosis, Mantoux test, Diaskintest, diagnostics.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (3): 70–75)https://vsp.spr-journal.ru/jour/article/view/615 |
| spellingShingle | L.V. Slogotskaya Ya.A. Kochetkov O.Yu. Senchikhina EFFECTIVENESS OF NEW SKIN TEST (DIASKINTEST) IN REVELATION OF INFECTED ADOLESCENTS WHO HAD A CONTACT WITH PATIENTS WITH TUBERCULOSIS Вопросы современной педиатрии |
| title | EFFECTIVENESS OF NEW SKIN TEST (DIASKINTEST) IN REVELATION OF INFECTED ADOLESCENTS WHO HAD A CONTACT WITH PATIENTS WITH TUBERCULOSIS |
| title_full | EFFECTIVENESS OF NEW SKIN TEST (DIASKINTEST) IN REVELATION OF INFECTED ADOLESCENTS WHO HAD A CONTACT WITH PATIENTS WITH TUBERCULOSIS |
| title_fullStr | EFFECTIVENESS OF NEW SKIN TEST (DIASKINTEST) IN REVELATION OF INFECTED ADOLESCENTS WHO HAD A CONTACT WITH PATIENTS WITH TUBERCULOSIS |
| title_full_unstemmed | EFFECTIVENESS OF NEW SKIN TEST (DIASKINTEST) IN REVELATION OF INFECTED ADOLESCENTS WHO HAD A CONTACT WITH PATIENTS WITH TUBERCULOSIS |
| title_short | EFFECTIVENESS OF NEW SKIN TEST (DIASKINTEST) IN REVELATION OF INFECTED ADOLESCENTS WHO HAD A CONTACT WITH PATIENTS WITH TUBERCULOSIS |
| title_sort | effectiveness of new skin test diaskintest in revelation of infected adolescents who had a contact with patients with tuberculosis |
| url | https://vsp.spr-journal.ru/jour/article/view/615 |
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