Paracrine signaling in cancer-associated fibroblasts: central regulators of the tumor immune microenvironment

Paracrine signaling in cancer-associated fibroblasts: central regulators of the tumor immune microenvironment

Abstract Despite groundbreaking advances in cancer immunotherapy, clinical efficacy remains constrained by the immunosuppressive tumor microenvironment (TME). As key stromal components within this TME, cancer-associated fibroblasts (CAFs) emerge as pivotal regulators of drug resistance and immune ev...

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Bibliographic Details
Main Authors: Ye Li, Longyun Wang, Wenzhe Ma, Jibiao Wu, Qibiao Wu, Changgang Sun
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Cancer-associated fibroblasts
Tumor immune microenvironment
Immune suppression
Paracrine signaling
Online Access:https://doi.org/10.1186/s12967-025-06744-4
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