Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation

QR Code

Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation

Hyaluronan, a key component of the extracellular matrix, plays a crucial role in joint development and maintenance. In order to determine the role of hyaluronan function in joint development and homeostasis, conditional loss-of-function experiments of Hyaluronan Synthase 2 (<i>Has2</i>)...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yingcui Li, Alexander Tress, Peter Maye, Kemar Edwards, Asiona Findletar, Nathaniel A. Dyment, Yu Yamaguchi, David W. Rowe, Gengyun Le-Chan, Sunny S. K. Chan, Kevin W.-H. Lo
Format:	Article
Language:	English
Published:	MDPI AG 2025-05-01
Series:	Biomedicines
Subjects:	synovial joint formation limb development cartilage homeostasis hyaluronan hyaluronan synthase 2 (<i>Has2</i>)
Online Access:	https://www.mdpi.com/2227-9059/13/6/1324
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Hyaluronan accumulation is associated with reduced hyaluronidase expression in renal cell carcinoma, with CD44, HAS1, and HYAL2 emerging as prognostic markers
by: Otto Jokelainen, et al.
Published: (2025-07-01)

The effect of aminooxy-linkers’ structure on the mechanical properties of hyaluronan-oxime hydrogels
by: Petra Sedova, et al.
Published: (2022-03-01)

Hyaluronan-Binding Protein Promotes Fibroblast Transformation and Heart Failure by Modulating the STAT5A–MMP13 Pathway
by: Hui Yan, et al.
Published: (2025-05-01)

Recent advances in exploring the properties and applications of hyaluronan
by: Qingkai Zeng, et al.
Published: (2024-09-01)

Effect of vasopressin on the expression of genes for key enzymes of interstitial hyaluronan turnover and concentration ability in WAG rat kidneys
by: L. N. Ivanova, et al.
Published: (2016-05-01)

The truncated isoform of the receptor for hyaluronan-mediated motility (RHAMMΔ163) modulates shelterin and telomerase reverse transcriptase transcription affecting telomerase activity
by: Kaustuv Basu
Published: (2025-06-01)

Chitosan-hyaluronan: promotion of mucociliary differentiation of respiratory epithelial cells and development of olfactory receptor neurons
by: Tsung-Wei Huang, et al.
Published: (2019-12-01)

Hyaluronic acid preparations in the treatment of osteoarthritis. Synvisk®(Hylan G-F 20): Efficacy and safety
by: Natalia Vladimirovna Chichasova
Published: (2013-12-01)

Agarose Gel Electrophoresis Reveals the Molecular Weight Distribution of Hyaluronan Produced by Orbital Fibroblasts
by: Erika Galgoczi, et al.
Published: (2025-05-01)

Rapid Replenishment of Phylloquinone in the Plasma and Liver Using Hyaluronan-Based Nanocapsules Reverses Endothelial Dysfunction in Mice
by: Kieronska-Rudek A, et al.
Published: (2025-06-01)

Efficacy of estradiol-dydrogesterone and auto-crosslinked hyaluronan gel in preventing intrauterine adhesions following missed miscarriage curettage: a retrospective observational study
by: Huilin Sheng, et al.
Published: (2025-07-01)

ANGIOGENIC AND ANGIOSTATIC CHEMOKINES LEVEL IN NORMAL SYNOVIAL FLUID
by: D. A. Zhebrun, et al.
Published: (2014-08-01)

Primary monophasic synovial sarcoma of the cervical esophagus confirmed by detection of the SS18-SSX2 fusion transcripts: case report and literature review
by: Ken Sasaki, et al.
Published: (2020-07-01)

A case of primary pulmonary synovial sarcoma
by: Keigo Ozono, et al.
Published: (2025-01-01)

Early progression of a pancreatic metastasis of synovial sarcoma after pancreatectomy
by: Mitsuyoshi Okazaki, et al.
Published: (2023-02-01)

Our experience of treatment of synovial chondromatosis of shoulder joint
by: V. V. Monastyrev, et al.
Published: (2017-09-01)

The role of a magnet-resonance tomography in diagnosis of a teno-synovial giant-cell tumor (the pigment villo-nodular synoviitis) of a knee joint
by: Yu. O. Kostogryz, et al.
Published: (2019-12-01)

The morphological structure of the synovial membrane in rheumatoid arthritis
by: Komarova E.B., et al.
Published: (2013-01-01)

Synovial sarcoma: molecular and biological features, the role of tissue microenvironment elements and their prognostic significance
by: D. V. Bulanov, et al.
Published: (2024-09-01)

A case of primary mesenteric synovial sarcoma: a challenging presentation
by: Nihed Abdessayed, et al.
Published: (2023-09-01)

Synovial organoids: From fundamental construction to groundbreaking applications in arthritic disorders
by: Xin Jin, et al.
Published: (2025-09-01)

Biochemical changes of synovial fluid in patients with osteoporosis of knee joint of various etiology
by: Y. L. Matveyeva, et al.
Published: (2013-09-01)

A Review of Assistive Devices in Synovial Joints: Records, Trends, and Classifications
by: Filiberto Cruz-Flores, et al.
Published: (2025-07-01)

Comparative characteristics of biochemical composition of synovial fluid of knee and elbow human joints
by: E. S. Spirkina, et al.
Published: (2013-04-01)

Quantitative morphological analysis of features of remodeling of the synovial membrane vasculature of the temporomandibular joint in hyperglycemia
by: A.H. Shulgai, et al.
Published: (2023-03-01)

LEVELS OF ANGIOGENESIS-REGULATORY CHEMOKINES IN THE SYNOVIAL FLUID OF PATIENTS WITH RHEUMATOID ARTHRITIS
by: D. A. Zhebrun, et al.
Published: (2015-03-01)

Synovial Fluid Extracellular Vesicles from Patients with Severe Osteoarthritis Differentially Promote a Pro-Catabolic, Inflammatory Chondrocyte Phenotype
by: Caitlin Ditchfield, et al.
Published: (2025-06-01)

Primary gastric synovial sarcoma resected by laparoscopic endoscopic cooperative surgery of the stomach: a case report
by: Ryosuke Shibata, et al.
Published: (2021-10-01)

Сellular composition and cytokine profile of synovial fluid in rheumatoid arthritis
by: E. V. Zhdanova, et al.
Published: (2022-11-01)

GENE EXPRESSION PROFILE AND MOLECULAR-GENETIC ANALYSIS OF SYNOVIAL SARCOMA AND EWING’ SARCOMA/PNET
by: V. М. Perelmuter, et al.
Published: (2016-02-01)

A Comparative Evaluation of Surgical Techniques Applied in Lumbar Synovial Cysts in Accordance with the Literature
by: Mustafa Emre Sarac, et al.
Published: (2025-07-01)

The role of synovial mesenchymal stem cell-derived exosomes in cartilage repair: a systematic review
by: Jiemao Su, et al.
Published: (2025-06-01)

Spontaneous regression of large-sized lumbar facet synovial cysts: two case reports and literature review
by: Hong Jin Kim, et al.
Published: (2025-07-01)

Synovial Cysts in the Temporomandibular Joint: a Case Report and Critical Review of the Literature
by: Ynn Maribo, et al.
Published: (2019-03-01)

SYNOVIAL MEMBRANE CHANGES IN PATIENTS WITH RHEUMATOID ARTHRITIS REVEALED DURING ARTHROSCOPY
by: E. B. Komarova
Published: (2017-07-01)

Machine Learning Strategies for Preoperative PJI Diagnosis: Integrative Analysis of Serum and Synovial Fluid Markers
by: Chen B, et al.
Published: (2025-07-01)

CULTURES OF FIBROBLAST-LIKE SYNOVIAL CELLS FROM PATIENTS WITH RHEUMATOID ARTHRITIS: PROPERTIES AND OPPORTUNITIES
by: M. A. Schneider, et al.
Published: (2016-04-01)

Integrated plasma and synovial membrane lipidomic profiling revealing the therapeutic effects of moxibustion in collagen-induced arthritis rat models
by: Jiamin Wen, et al.
Published: (2025-06-01)

Regularities in disturbances of cytological composition of synovial fluid and activity of free radical oxidative processes in case of experimental joint injury and possibility of their pathogenetic correction
by: A. N. Zahvatov, et al.
Published: (2018-09-01)

PH-DEPENDENT MECHANISM OF ENERGY TRANSFORMATION IN SYNOVIAL FLUID CELLS IN KNEE OSTEOARTHRITIS AND EFFECT OF CHONDROITIN SULFATE
by: VI Shishkin, et al.
Published: (2007-10-01)