Exploring the role of metabolomics in kidney transplantation: a systematic review of the literature
BackgroundSerum creatinine and proteinuria remain the most frequently used test for monitoring allograft function. However, they are non-specific and insensitive markers. Metabolomics is an emerging field, dealing with the high-throughput identification and quantification of small molecules metaboli...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534875/full |
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| author | Cezar Valeriu Băluţă Cezar Valeriu Băluţă Luminiţa Voroneanu Luminiţa Voroneanu Ionuţ Nistor Ionuţ Nistor Lucian Siriteanu Lucian Siriteanu Andreea Simona Covic Andreea Simona Covic Raluca Erika Irimie-Băluţă Raluca Erika Irimie-Băluţă Mehmet Kanbay Adelina Vasilica Miron Adelina Vasilica Miron Adrian Constantin Covic Adrian Constantin Covic |
| author_facet | Cezar Valeriu Băluţă Cezar Valeriu Băluţă Luminiţa Voroneanu Luminiţa Voroneanu Ionuţ Nistor Ionuţ Nistor Lucian Siriteanu Lucian Siriteanu Andreea Simona Covic Andreea Simona Covic Raluca Erika Irimie-Băluţă Raluca Erika Irimie-Băluţă Mehmet Kanbay Adelina Vasilica Miron Adelina Vasilica Miron Adrian Constantin Covic Adrian Constantin Covic |
| author_sort | Cezar Valeriu Băluţă |
| collection | DOAJ |
| description | BackgroundSerum creatinine and proteinuria remain the most frequently used test for monitoring allograft function. However, they are non-specific and insensitive markers. Metabolomics is an emerging field, dealing with the high-throughput identification and quantification of small molecules metabolites. We aimed to systematically review all available data regarding kidney transplantation and metabolomics.MethodsThis is a systematic review evaluating metabolomic usage in kidney transplant patients. A comprehensive search was assembled in the time span extending from inception until March 2024 across MEDLINE (PubMed), Embase and Cochrane. In addition to the databases above, eligible citation were sought through the screening of ClinicalTrials.gov and Google Scholar. Two authors assessed potential citations for eligibility and quality and extracted all data.ResultsA total of 57 articles were identified for inclusion (totaling 3821 patients), containing different methodologies and outcomes related to metabolic profiling. We aimed to offer support for finding new biomarkers that could aid in the evaluation of the kidney transplant patient, covering pathophysiological mechanisms and exploring avenues for personalized care.ConclussionOur systematic review underlines the possible role of metabolomics in monitoring kidney transplant patients. By integrating data from numerous studies, we have detected possible new biomarkers that might transform the method we screen kidney transplant recipients. |
| format | Article |
| id | doaj-art-0aa3d875fe04445f9de7256ea24e07a3 |
| institution | Matheson Library |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-0aa3d875fe04445f9de7256ea24e07a32025-06-30T14:56:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.15348751534875Exploring the role of metabolomics in kidney transplantation: a systematic review of the literatureCezar Valeriu Băluţă0Cezar Valeriu Băluţă1Luminiţa Voroneanu2Luminiţa Voroneanu3Ionuţ Nistor4Ionuţ Nistor5Lucian Siriteanu6Lucian Siriteanu7Andreea Simona Covic8Andreea Simona Covic9Raluca Erika Irimie-Băluţă10Raluca Erika Irimie-Băluţă11Mehmet Kanbay12Adelina Vasilica Miron13Adelina Vasilica Miron14Adrian Constantin Covic15Adrian Constantin Covic16Grigore T. Popa University of Medicine and Pharmacy, Iaşi, RomaniaSpitalul Clinic Dr. C. I. Parhon, Iaşi, RomaniaGrigore T. Popa University of Medicine and Pharmacy, Iaşi, RomaniaSpitalul Clinic Dr. C. I. Parhon, Iaşi, RomaniaGrigore T. Popa University of Medicine and Pharmacy, Iaşi, RomaniaSpitalul Clinic Dr. C. I. Parhon, Iaşi, RomaniaGrigore T. Popa University of Medicine and Pharmacy, Iaşi, RomaniaSpitalul Clinic Dr. C. I. Parhon, Iaşi, RomaniaGrigore T. Popa University of Medicine and Pharmacy, Iaşi, RomaniaSpitalul Clinic Dr. C. I. Parhon, Iaşi, RomaniaGrigore T. Popa University of Medicine and Pharmacy, Iaşi, RomaniaSfanta Parascheva Clinical Hospital for Infectious Diseases, Iaşi, RomaniaDepartment of Medicine, School of Medicine, Koc University, Istanbul, TürkiyeGrigore T. Popa University of Medicine and Pharmacy, Iaşi, RomaniaSpitalul Clinic Dr. C. I. Parhon, Iaşi, RomaniaGrigore T. Popa University of Medicine and Pharmacy, Iaşi, RomaniaSpitalul Clinic Dr. C. I. Parhon, Iaşi, RomaniaBackgroundSerum creatinine and proteinuria remain the most frequently used test for monitoring allograft function. However, they are non-specific and insensitive markers. Metabolomics is an emerging field, dealing with the high-throughput identification and quantification of small molecules metabolites. We aimed to systematically review all available data regarding kidney transplantation and metabolomics.MethodsThis is a systematic review evaluating metabolomic usage in kidney transplant patients. A comprehensive search was assembled in the time span extending from inception until March 2024 across MEDLINE (PubMed), Embase and Cochrane. In addition to the databases above, eligible citation were sought through the screening of ClinicalTrials.gov and Google Scholar. Two authors assessed potential citations for eligibility and quality and extracted all data.ResultsA total of 57 articles were identified for inclusion (totaling 3821 patients), containing different methodologies and outcomes related to metabolic profiling. We aimed to offer support for finding new biomarkers that could aid in the evaluation of the kidney transplant patient, covering pathophysiological mechanisms and exploring avenues for personalized care.ConclussionOur systematic review underlines the possible role of metabolomics in monitoring kidney transplant patients. By integrating data from numerous studies, we have detected possible new biomarkers that might transform the method we screen kidney transplant recipients.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534875/fullkidney transplanationsystematic reviewmetabolomicsallograft functionkidney rejectmetabolites |
| spellingShingle | Cezar Valeriu Băluţă Cezar Valeriu Băluţă Luminiţa Voroneanu Luminiţa Voroneanu Ionuţ Nistor Ionuţ Nistor Lucian Siriteanu Lucian Siriteanu Andreea Simona Covic Andreea Simona Covic Raluca Erika Irimie-Băluţă Raluca Erika Irimie-Băluţă Mehmet Kanbay Adelina Vasilica Miron Adelina Vasilica Miron Adrian Constantin Covic Adrian Constantin Covic Exploring the role of metabolomics in kidney transplantation: a systematic review of the literature Frontiers in Immunology kidney transplanation systematic review metabolomics allograft function kidney reject metabolites |
| title | Exploring the role of metabolomics in kidney transplantation: a systematic review of the literature |
| title_full | Exploring the role of metabolomics in kidney transplantation: a systematic review of the literature |
| title_fullStr | Exploring the role of metabolomics in kidney transplantation: a systematic review of the literature |
| title_full_unstemmed | Exploring the role of metabolomics in kidney transplantation: a systematic review of the literature |
| title_short | Exploring the role of metabolomics in kidney transplantation: a systematic review of the literature |
| title_sort | exploring the role of metabolomics in kidney transplantation a systematic review of the literature |
| topic | kidney transplanation systematic review metabolomics allograft function kidney reject metabolites |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534875/full |
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