Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population
BackgroundWe aimed to investigate the correlation between central thyroid hormone sensitivity and Hypertriglyceridemia (HTG) in euthyroid population.MethodsA total of 833 individuals who underwent physical examinations were randomly selected. Biochemical parameters including thyroid hormones (THs),...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Endocrinology |
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| author | Yu Gong Yu Gong Guojuan Wang Qianqian Zhang Xu Jiang Zhangxiang Zhu Ying Li |
| author_facet | Yu Gong Yu Gong Guojuan Wang Qianqian Zhang Xu Jiang Zhangxiang Zhu Ying Li |
| author_sort | Yu Gong |
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| description | BackgroundWe aimed to investigate the correlation between central thyroid hormone sensitivity and Hypertriglyceridemia (HTG) in euthyroid population.MethodsA total of 833 individuals who underwent physical examinations were randomly selected. Biochemical parameters including thyroid hormones (THs), liver and kidney functions, blood glucose, and blood lipids were measured. Central TH sensitivity was evaluated using the thyroid feedback quantile-based index (TFQI), thyroid-stimulating hormone index (TSHI) and thyrotropin thyroxine resistance index (TT4RI). We analyzed the relationship between central TH sensitivity and triglyceride (TG) level using smooth curve fitting and threshold effect analysis and trend tests in multiple regression equations.ResultsTSHI (β=0.158, P=0.0443) was positively correlated with TG, while TT4RI (β=0.018, P=0.0112, inflection point: 25.809) and TFQI (β=0.798, P=0.0066, inflection point: -0.194) were both positively correlated with TG before the inflection points. Subgroup analyses revealed these relationships were particularly pronounced in females (TT4RI β=0.026, P=0.0205, inflection point: 22.487; TFQI β=0.780, P=0.0133, inflection point: -0.142), males (TFQI β=1.954, P=0.0100, inflection point: -0.395), individuals with age <65 years (TT4RI β=0.019, P=0.0119, inflection point: 25.809; TFQI β=0.878, P=0.0060, inflection point: -0.206), and individuals with BMI<28kg/m² (TT4RI β=0.026, P=0.0090, inflection point: 21.515; TFQI β=0.735, P=0.0132, inflection point: -0.173), all showing positive correlations before the point correlations. Tests for trend in multiple regression equations showed that with the increased quartiles of TT4RI (OR=1.321, P=0.00118) and TSHI (OR=1.253, P=0.00784), the risk of HTG increased correspondingly. For per SD increase in TT4RI, the odds of HTG increased by 36.5% (OR=1.365, P=0.00703). For per SD increase in TSHI, the odds of HTG increased by 19.1% (OR=1.191, P=0.06648).ConclusionImpaired central thyroid hormone sensitivity is associated with increased triglyceride in euthyroid population, this association is more pronounced in individuals with aged<65 years and BMI<28kg/m2. Impaired central thyroid hormone sensitivity may be an independent risk factor for hypertriglyceridemia. |
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| spelling | doaj-art-0a918ed2bddf40a8b552e3493bafb6ea2025-07-14T04:10:09ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-07-011610.3389/fendo.2025.16169071616907Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid populationYu Gong0Yu Gong1Guojuan Wang2Qianqian Zhang3Xu Jiang4Zhangxiang Zhu5Ying Li6Department of Endocrinology and Metabolism, the Third Affiliated Hospital of Anhui Medical University (The First People’s Hospital of Hefei), Hefei, Anhui, ChinaGraduate School, Bengbu Medical University, Bengbu, Anhui, ChinaDepartment of Endocrinology and Metabolism, the Third Affiliated Hospital of Anhui Medical University (The First People’s Hospital of Hefei), Hefei, Anhui, ChinaDepartment of Endocrinology and Metabolism, the Third Affiliated Hospital of Anhui Medical University (The First People’s Hospital of Hefei), Hefei, Anhui, ChinaDepartment of Endocrinology and Metabolism, the Third Affiliated Hospital of Anhui Medical University (The First People’s Hospital of Hefei), Hefei, Anhui, ChinaDepartment of Endocrinology and Metabolism, the Third Affiliated Hospital of Anhui Medical University (The First People’s Hospital of Hefei), Hefei, Anhui, ChinaDepartment of Endocrinology and Metabolism, the Third Affiliated Hospital of Anhui Medical University (The First People’s Hospital of Hefei), Hefei, Anhui, ChinaBackgroundWe aimed to investigate the correlation between central thyroid hormone sensitivity and Hypertriglyceridemia (HTG) in euthyroid population.MethodsA total of 833 individuals who underwent physical examinations were randomly selected. Biochemical parameters including thyroid hormones (THs), liver and kidney functions, blood glucose, and blood lipids were measured. Central TH sensitivity was evaluated using the thyroid feedback quantile-based index (TFQI), thyroid-stimulating hormone index (TSHI) and thyrotropin thyroxine resistance index (TT4RI). We analyzed the relationship between central TH sensitivity and triglyceride (TG) level using smooth curve fitting and threshold effect analysis and trend tests in multiple regression equations.ResultsTSHI (β=0.158, P=0.0443) was positively correlated with TG, while TT4RI (β=0.018, P=0.0112, inflection point: 25.809) and TFQI (β=0.798, P=0.0066, inflection point: -0.194) were both positively correlated with TG before the inflection points. Subgroup analyses revealed these relationships were particularly pronounced in females (TT4RI β=0.026, P=0.0205, inflection point: 22.487; TFQI β=0.780, P=0.0133, inflection point: -0.142), males (TFQI β=1.954, P=0.0100, inflection point: -0.395), individuals with age <65 years (TT4RI β=0.019, P=0.0119, inflection point: 25.809; TFQI β=0.878, P=0.0060, inflection point: -0.206), and individuals with BMI<28kg/m² (TT4RI β=0.026, P=0.0090, inflection point: 21.515; TFQI β=0.735, P=0.0132, inflection point: -0.173), all showing positive correlations before the point correlations. Tests for trend in multiple regression equations showed that with the increased quartiles of TT4RI (OR=1.321, P=0.00118) and TSHI (OR=1.253, P=0.00784), the risk of HTG increased correspondingly. For per SD increase in TT4RI, the odds of HTG increased by 36.5% (OR=1.365, P=0.00703). For per SD increase in TSHI, the odds of HTG increased by 19.1% (OR=1.191, P=0.06648).ConclusionImpaired central thyroid hormone sensitivity is associated with increased triglyceride in euthyroid population, this association is more pronounced in individuals with aged<65 years and BMI<28kg/m2. Impaired central thyroid hormone sensitivity may be an independent risk factor for hypertriglyceridemia.https://www.frontiersin.org/articles/10.3389/fendo.2025.1616907/fullthyroid hormone sensitivityhypertriglyceridemiathyroid feedback quantile-based indexthyroid-stimulating hormone indexthyrotropin thyroxine resistance index |
| spellingShingle | Yu Gong Yu Gong Guojuan Wang Qianqian Zhang Xu Jiang Zhangxiang Zhu Ying Li Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population Frontiers in Endocrinology thyroid hormone sensitivity hypertriglyceridemia thyroid feedback quantile-based index thyroid-stimulating hormone index thyrotropin thyroxine resistance index |
| title | Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population |
| title_full | Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population |
| title_fullStr | Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population |
| title_full_unstemmed | Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population |
| title_short | Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population |
| title_sort | impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population |
| topic | thyroid hormone sensitivity hypertriglyceridemia thyroid feedback quantile-based index thyroid-stimulating hormone index thyrotropin thyroxine resistance index |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1616907/full |
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