Lung Adenocarcinoma With Extensive Vascular Invasion and Retinal Metastasis: A Case Report
ABSTRACT A 34‐year‐old Ghanaian male with no past medical history presented to our hospital with dyspnoea, left‐sided chest pain, and left‐eye visual disturbance. Imaging revealed a large mediastinal mass with vascular invasion, left pleural and skeletal metastases. A lung biopsy confirmed lung aden...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Respirology Case Reports |
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| Online Access: | https://doi.org/10.1002/rcr2.70170 |
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| author | Bassem Alhariri Arwa Elfatih Osman Osama Elhassan Mohamed Elfatih Aya Mohamed Kheir Razan Elkhatib |
| author_facet | Bassem Alhariri Arwa Elfatih Osman Osama Elhassan Mohamed Elfatih Aya Mohamed Kheir Razan Elkhatib |
| author_sort | Bassem Alhariri |
| collection | DOAJ |
| description | ABSTRACT A 34‐year‐old Ghanaian male with no past medical history presented to our hospital with dyspnoea, left‐sided chest pain, and left‐eye visual disturbance. Imaging revealed a large mediastinal mass with vascular invasion, left pleural and skeletal metastases. A lung biopsy confirmed lung adenocarcinoma (LUAD) with mixed solid and lepidic growth patterns, showing 80% PD‐L1 expression. Positron emission tomography (PET) identified a highly active lesion in the left eye, suggestive of retinal metastasis. Ophthalmologic evaluation confirmed retinal involvement. Given ROS1 positivity, Crizotinib was initially prescribed but switched to Lorlatinib due to concerns regarding retinal involvement. The patient demonstrated rapid clinical improvement, including notable visual recovery, with stable performance status after 1 month. This case underscores LUAD's potential for atypical metastasis, such as to the retina, necessitating comprehensive assessment and personalised management strategies. The shift from Crizotinib to Lorlatinib highlights the importance of targeted therapy in managing advanced NSCLC with rare metastatic involvement. |
| format | Article |
| id | doaj-art-0a84c12c57a8488a872d3e7c4ce8c4cc |
| institution | Matheson Library |
| issn | 2051-3380 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj-art-0a84c12c57a8488a872d3e7c4ce8c4cc2025-06-26T15:52:48ZengWileyRespirology Case Reports2051-33802025-06-01136n/an/a10.1002/rcr2.70170Lung Adenocarcinoma With Extensive Vascular Invasion and Retinal Metastasis: A Case ReportBassem Alhariri0Arwa Elfatih1Osman Osama Elhassan2Mohamed Elfatih3Aya Mohamed Kheir4Razan Elkhatib5Department of Medicine Hamad Medical Corporation Doha QatarMedical Education Department Hamad Medical Corporation Doha QatarMedical Education Department Hamad Medical Corporation Doha QatarMedical Education Department Hamad Medical Corporation Doha QatarMedical Education Department Hamad Medical Corporation Doha QatarMedical Education Department Hamad Medical Corporation Doha QatarABSTRACT A 34‐year‐old Ghanaian male with no past medical history presented to our hospital with dyspnoea, left‐sided chest pain, and left‐eye visual disturbance. Imaging revealed a large mediastinal mass with vascular invasion, left pleural and skeletal metastases. A lung biopsy confirmed lung adenocarcinoma (LUAD) with mixed solid and lepidic growth patterns, showing 80% PD‐L1 expression. Positron emission tomography (PET) identified a highly active lesion in the left eye, suggestive of retinal metastasis. Ophthalmologic evaluation confirmed retinal involvement. Given ROS1 positivity, Crizotinib was initially prescribed but switched to Lorlatinib due to concerns regarding retinal involvement. The patient demonstrated rapid clinical improvement, including notable visual recovery, with stable performance status after 1 month. This case underscores LUAD's potential for atypical metastasis, such as to the retina, necessitating comprehensive assessment and personalised management strategies. The shift from Crizotinib to Lorlatinib highlights the importance of targeted therapy in managing advanced NSCLC with rare metastatic involvement.https://doi.org/10.1002/rcr2.70170lung adenocarcinomanon‐small cell lung cancerretinal metastasistargeted therapyvascular invasion |
| spellingShingle | Bassem Alhariri Arwa Elfatih Osman Osama Elhassan Mohamed Elfatih Aya Mohamed Kheir Razan Elkhatib Lung Adenocarcinoma With Extensive Vascular Invasion and Retinal Metastasis: A Case Report Respirology Case Reports lung adenocarcinoma non‐small cell lung cancer retinal metastasis targeted therapy vascular invasion |
| title | Lung Adenocarcinoma With Extensive Vascular Invasion and Retinal Metastasis: A Case Report |
| title_full | Lung Adenocarcinoma With Extensive Vascular Invasion and Retinal Metastasis: A Case Report |
| title_fullStr | Lung Adenocarcinoma With Extensive Vascular Invasion and Retinal Metastasis: A Case Report |
| title_full_unstemmed | Lung Adenocarcinoma With Extensive Vascular Invasion and Retinal Metastasis: A Case Report |
| title_short | Lung Adenocarcinoma With Extensive Vascular Invasion and Retinal Metastasis: A Case Report |
| title_sort | lung adenocarcinoma with extensive vascular invasion and retinal metastasis a case report |
| topic | lung adenocarcinoma non‐small cell lung cancer retinal metastasis targeted therapy vascular invasion |
| url | https://doi.org/10.1002/rcr2.70170 |
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