The cardiotropic properties of ZMEI-3 compound – a potential inhibitor of Epac proteins

The cardiotropic properties of ZMEI-3 compound – a potential inhibitor of Epac proteins

Introduction. It is known that the allosteric effector of cAMP, in addition to protein kinase A, is the Epac regulatory proteins, which in cardiomyocytes play a key role in the electromechanical coupling control and their rhythmic activity. However, under pathological conditions, abnormal activity o...

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Bibliographic Details
Main Authors: S. A. Kryzhanovskii, G. V. Mokrov, I. B. Tsorin, E. O. Ionova, M. B. Vititnova, V. N. Stolyaruk, I. A. Miroshkina, A. V. Sorokina, A. D. Durnev
Format: Article
Language:Russian
Published: LLC “Publisher OKI” 2025-01-01
Series:Фармакокинетика и Фармакодинамика
Subjects:
epac proteins
epac protein antagonists
compound zmei-3
cardiac arrhythmias
alcoholic cardiomyopathy
myocardial contractility
rats
Online Access:https://www.pharmacokinetica.ru/jour/article/view/437
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