Simultaneous Determination of Nirmatrelvir and Ritonavir in Human Plasma by HPLC-MS/MS

QR Code

Simultaneous Determination of Nirmatrelvir and Ritonavir in Human Plasma by HPLC-MS/MS

Introduction. SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus 2) is expected to remain a persistent global threat. Therefore, development of coronavirus disease 2019 (COVID-19) drugs is the most urgent global issue. Nirmatrelvir and ritonavir combination is an oral antiviral drug c...

Full description

Saved in:

Bibliographic Details
Main Authors:	T. N. Komarov, P. K. Karnakova, O. A. Archakova, D. S. Shchelgacheva, N. S. Bagaeva, I. E. Shohin, K. Ya. Zaslavskaya, P. A. Bely
Format:	Article
Language:	Russian
Published:	LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2023-05-01
Series:	Разработка и регистрация лекарственных средств
Subjects:	nirmatrelvir ritonavir covid-19 plasma hplc-ms/ms validation pharmacokinetics
Online Access:	https://www.pharmjournal.ru/jour/article/view/1493
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Simultaneous Determination of Candesartan and Hydrochlorothiazide in Human Plasma by HPLC-MS/MS
by: P. K. Karnakova, et al.
Published: (2021-11-01)

Development and Validation of Atazanavir and Ritonavir Determination in Human Plasma by HPLC-MS Method
by: T. N. Komarov, et al.
Published: (2020-02-01)

Determination of Favipiravir in Human Blood Plasma by HPLC-MS/MS
by: T. N. Komarov, et al.
Published: (2023-09-01)

Simultaneous Determination of Major Molnupiravir Metabolite (β-D-N4-hydroxycytidine) and Favipiravir in Human Plasma by HPLC-MS/MS
by: T. N. Komarov, et al.
Published: (2023-02-01)

Development and Validation of an HPLC-MS/MS Method for Quantification of Apixaban in Human Plasma
by: U. D. Filonova, et al.
Published: (2024-03-01)

Development and Validation of an HPLC-MS/MS Method for the Quantitative Determination of Etmaben in Human Blood Plasma
by: P. K. Karnakova, et al.
Published: (2024-03-01)

Development and Validation of Tranexamic Acid Determination in Human Plasma by HPLC-MS/MS method
by: A. V. Aleshina, et al.
Published: (2021-05-01)

Development and Validation of Pomalidomide Determination in Human Plasma by HPLC-MS/MS Method
by: T. N. Komarov, et al.
Published: (2020-11-01)

Development and Validation of Valganciclovir and its Active Metabolite Ganciclovir Determination in Human Plasma by HPLC-MS/MS Method
by: T. N. Komarov, et al.
Published: (2021-02-01)

Bioequivalence study of generic nirmatrelvir in healthy volunteers
by: R. A. Oseshnyuk, et al.
Published: (2023-05-01)

DETERMINATION OF CAPECITABINE AND ITS ACTIVE METABOLITE 5-FLUOROURACIL IN BLOOD PLASMA BY HPLC-MS/MS
by: E. S. Melnikov, et al.
Published: (2019-01-01)

MODERN DIRECTED ANTIVIRAL COVID-19 THERAPY: RESULTS OF MULTICENTER CLINICAL EFFECTIVENESS AND SAFETY STUDY OF FIXED NIRMATRELVIR+RITONAVIR COMBINATION
by: L. A. Balykova, et al.
Published: (2022-10-01)

Efficacy of Nirmatrelvir tablet/Ritonavir tablet in patients infected with COVID-19 aged 90 years and older
by: WEI Xueman, et al.
Published: (2025-05-01)

HPLC-MS/MS method development and validation for the determination of tetradecapeptide in human plasma
by: M. A. Tokareva, et al.
Published: (2024-06-01)

Development and Validation of Salbutamol, Bromhexine, Ambroxol and Guauaifenesin Determination in Human Plasma by HPLC-MS/MS Method
by: T. N. Komarov, et al.
Published: (2019-11-01)

Is the Combination Nirmatrelvir Plus Ritonavir Effective for Treating or Preventing COVID-19?
by: article Editorial
Published: (2022-12-01)

Molnupiravir and Nirmatrelvir/Ritonavir: The New Available Antiviral Options for COVID-19
by: Samuel Theodorus Sutanto, et al.
Published: (2023-01-01)

Risk Factors for Seeking Medical Care Following Nirmatrelvir-Ritonavir (Paxlovid) Treatment for COVID-19: “Symptom Rebound”
by: Ashish Bhargava, et al.
Published: (2025-05-01)

Development and Validation of HPLC-MS/MS Method for Busereline Quantitation in Animal Blood Plasma
by: E. N. Fisher, et al.
Published: (2019-09-01)

Development and validation of the method for the quantitative determination of methotrexate in a transport medium by HPLC-MS/MS
by: P. Yu. Mylnikov, et al.
Published: (2021-09-01)

Real-world effectiveness and economic analysis of nirmatrelvir/ritonavir, remdesivir, and molnupiravir for treatment of COVID-19 among ambulatory patients in Thailand
by: Sirapat Korwiwattanakan, et al.
Published: (2025-08-01)

Mitoxantrone Quantification by HPLC-MS/MS in Caco-2 Culture Media
by: Yu. S. Tranova, et al.
Published: (2023-03-01)

The experience in the development and validation of method for testosterone measurement in blood serum of premenopausal women using HPLC-MS/MS
by: L. V. Suturina, et al.
Published: (2022-12-01)

HPLC-MS/MS Method for Quantitation of Sildenafil and Its Active Metabolite in Human Plasma
by: G. G. Rodionov, et al.
Published: (2020-09-01)

Determination of Lappaconitin, Diterpene Alkaloide Obtained from Plants <i>Aconitum leucostomum</i>, and its Active Metabolite N-desacetyllappaconitin in Human Plasma and Blood
by: O. A. Archakova, et al.
Published: (2021-08-01)

EXPRESS METHOD FOR DETERMINATION OF ENALAPRIL AND ENALAPRILAT IN HUMAN SERUM BY HPLC-MS/MS
by: T. A. Rodina, et al.
Published: (2019-01-01)

Development and Validation of Eltrombopag Determination in Human Plasma Blood by HPLC-MS Method
by: А. М. AL-Dhuraibi, et al.
Published: (2022-11-01)

Cost-effectiveness analysis of nirmatrelvir/ritonavir in adult patients at high risk of progressing to severe COVID-19
by: Carolina Moreno, et al.
Published: (2025-07-01)

Quantitative determination of monoamine neurotransmitters in rat brain homogenates using HPLC-MS/MS
by: N. S. Popov, et al.
Published: (2023-01-01)

Development and validation of a method for the quantitative determination of monoamine neurotransmitters and their metabolites in rat brain tissue using HPLC-MS/MS
by: A. L. Khokhlov, et al.
Published: (2024-03-01)

Development and Validation of Tadalafil Determination in Human Plasma by HPLC-MS Method
by: D. S. Bogdanova, et al.
Published: (2019-05-01)

Development and Validation of a UHPLC-MS/MS Method for Ciprofol Detection in Plasma: Application in Clinical Pharmacokinetic Studies
by: Zhu J, et al.
Published: (2025-07-01)

Development of a High-Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS) Method to Determine the Presence of Rivastigmine in Human Plasma in Clinical Studies of Comparative Pharmacokinetics
by: M. S. Dolov, et al.
Published: (2023-02-01)

Bioequivalence study of ondansetron tablets by HPLC-MS
by: E. S. Stepanova, et al.
Published: (2014-04-01)

Development and Validation of HPLC-UV Method for the Determination of Favipiravir in Human Plasma
by: T. N. Komarov, et al.
Published: (2022-09-01)

Chromatography-tandem MASS spectrometry (HPLC-MS/MS) for the detection of valproic acid and its metabolites in blood plasma
by: A. S. Malygin, et al.
Published: (2018-08-01)

Comparative study of perindopril and perindopril metabolite pharmacokinetics using the HPLC/MS method
by: L. M. Krasnykh, et al.
Published: (2018-02-01)

Pharmacokinetics Study of a New Isoxazole Derivative in Rats Using HPLC-MS/MS for Blood Sample Analysis
by: I. I. Yaichkov, et al.
Published: (2024-07-01)

Using gc-ms and hplc-ms/ms for analyzing impurities in triethylene glycol accumulating in the process of natural gas drying
by: M. N. Usachev, et al.
Published: (2015-08-01)

Development and validation of a high-performance liquid chromatography with tandem mass spectrometry method for quantification of tofacitinib in human plasma
by: E. S. Vetrova, et al.
Published: (2024-06-01)