PIEZO1 variant implications for biological understanding and human health

PIEZO1 variant implications for biological understanding and human health

The large membrane protein PIEZO1 assembles as trimers to form exceptional mechanical force-sensing ion channels of eukaryotes. When these channels are activated by force, cell membrane permeability to calcium ions and other ions increases rapidly, coupling force to cell function through ionic contr...

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Bibliographic Details
Main Authors: Chew W. Cheng, Sophie L. Earle, Oleksandr V. Povstyan, Chloe Randall, Katie A. Smith, Marjolaine Debant, Fraser L. Macrae, Daniel G. Beech, Anna McGrane, Fiona Bartoli, Eulashini Chuntharpursat-Bon, Richard M. Cubbon, Kathryn J. Griffin, Marc A. Bailey, Antreas C. Kalli, Lara C. Morley, Klaus K. Witte, David J. Beech
Format: Article
Language:English
Published: The Royal Society 2025-07-01
Series:Open Biology
Subjects:
non-selective cation channel
calcium channel
calcium signalling
mechanical force
shear stress
endothelium
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.240345
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https://royalsocietypublishing.org/doi/10.1098/rsob.240345

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