Dynamic versus fixed cerebral perfusion pressure targets in paediatric traumatic brain injury: a STARSHIP analysisResearch in context

Dynamic versus fixed cerebral perfusion pressure targets in paediatric traumatic brain injury: a STARSHIP analysisResearch in context

Summary: Background: Cerebral perfusion pressure (CPP) represents a key target for intensive care management of paediatric traumatic brain injury (TBI) patients. Current guidelines recommend a CPP target within the range of 40–50 mmHg but emphasise that these may depend on patient age and the state...

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Main Authors: C.A. Smith, S.Y. Bögli, M.M. Placek, M. Cabeleira, D. White, E. Daubney, A. Young, E. Beqiri, R. Kayani, R. O'Donnell, N. Pathan, S. Watson, A. Maw, M. Garnett, H.K. Kanthimathinathan, H. Bangalore, S. Sundararajan, G. Subramanian, D. Raffaj, S. Lampariello, A. Sarfatti, A. Mayer, O. Ross, M. Czosnyka, P.J. Hutchinson, P. Smielewski, S. Agrawal, Shruti Agrawal, Peter Smielewski, Peter J. Hutchinson, Stefan Yu Bögli, Claudia A. Smith, Carly Tooke, Caroline Payne, Holly Belfield, Amisha Mistry, Collette Spencer, Claire Jennings, Lara Bunni, Laura Anderson, Emily Morgan, Melanie James, Rebecca Beckley, Tahnima Khatun, Hafiza Khatun, Olivia Nugent, Richard Aldridge, Ruth Morgan, Julie Morcombe, Martin Quinton, Catherine Postlethwaite, Jenny Pond, Jessica Cutler, Caitlin Oxford, Marek Czosnyka, Michal Placek, Manuel Cabaleira, Deborah White, Esther Daubney, Adam Young, Erta Beqiri, Riaz Kayani, Roddy O'Donnell, Nazima Pathan, Suzanna Watson, Anna Maw, Matthew Garnett, Hari Krishnan Kanthimathinathan, Harish Bangalore, Santosh Sundararajan, Gayathri Subramanian, Dusan Raffaj, Simona Lampariello, Avishay Sarfatti, Anton Mayer, Oliver Ross
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:EClinicalMedicine
Subjects:
Paediatric traumatic brain injury
Multimodality neuromonitoring
Intensive care management
Cerebral perfusion pressure
Cerebrovascular autoregulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025003025
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