Synergistic Efficacy of Doxycycline and Florfenicol Against <i>Aeromonas hydrophilia</i> and <i>Morganella morganii</i> Infections in <i>Pelodiscus sinensis</i> with Skin Ulcer Disease

Synergistic Efficacy of Doxycycline and Florfenicol Against <i>Aeromonas hydrophilia</i> and <i>Morganella morganii</i> Infections in <i>Pelodiscus sinensis</i> with Skin Ulcer Disease

The intensive farming of <i>Pelodiscus sinensis</i> (<i>P. sinensis</i>) for its medicinal and economic value has led to an increased incidence of bacterial skin infections, commonly treated with antibiotics. However, rising antibiotic resistance has reduced the effectiveness...

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Main Authors: Ziwen Cai, Wenjing Zhang, Yun Wang, Zhaoying Yang, Xiaolei Lei, Xiaomin Shi, Mengze Du, Xiaoye Liu
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Veterinary Sciences
Subjects:
<i>Pelodiscus sinensis</i>
skin ulcer disease
antibiotic resistance
combination therapy
Online Access:https://www.mdpi.com/2306-7381/12/7/611
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Summary:The intensive farming of <i>Pelodiscus sinensis</i> (<i>P. sinensis</i>) for its medicinal and economic value has led to an increased incidence of bacterial skin infections, commonly treated with antibiotics. However, rising antibiotic resistance has reduced the effectiveness of these treatments, highlighting an urgent need for alternative therapeutic approaches. In this study, we isolated and identified pathogenic bacteria (<i>Aeromonas</i> and <i>Morganella</i>) from <i>P. sinensis</i> affected by skin ulcer disease at a turtle farm in Beijing. Antibiotic resistance was evaluated using the checkerboard microdilution method and the in vitro antibacterial efficacy of a florfenicol–doxycycline combination therapy was assessed. A total of 30 bacterial isolates were obtained, primarily <i>Morganella</i> and <i>Aeromonas</i> species. Among these, 83.3% of <i>Morganella</i> and 57.14% of <i>Aeromonas</i> isolates demonstrated multidrug-resistance. The florfenicol–doxycycline combination yielded lower fractional inhibitory concentration (FIC) values, indicating synergistic or additive effects. Animal experiments have shown that florfenicol in combination with doxycycline can achieve better therapeutic effects with less drug. These findings support that combination antibiotic therapies help in managing skin ulcer disease in <i>P. sinensis</i> and offer valuable insights for clinical applications.
ISSN:2306-7381

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