Cutis Verticis Gyrata Differential Diagnosis: Clinical Case
Background. Cutis verticis gyrata is rare benign scalp disorder characterized by excessive skin and subcutaneous tissue proliferation and hypertrophy. Nowadays, there are three forms of this disease with various developmental mechanisms and associated manifestations. Clinical case description. This...
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"Paediatrician" Publishers LLC
2024-11-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/3609 |
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| author | Tatiana S. Belysheva Ekaterina E. Zelenova Tatiana A. Gassan Eduard T. Ambarchyan Malika I. Denieva Yana V. Vishnevskaya Tatiana V. Nasedkina Nikolay N. Murashkin |
| author_facet | Tatiana S. Belysheva Ekaterina E. Zelenova Tatiana A. Gassan Eduard T. Ambarchyan Malika I. Denieva Yana V. Vishnevskaya Tatiana V. Nasedkina Nikolay N. Murashkin |
| author_sort | Tatiana S. Belysheva |
| collection | DOAJ |
| description | Background. Cutis verticis gyrata is rare benign scalp disorder characterized by excessive skin and subcutaneous tissue proliferation and hypertrophy. Nowadays, there are three forms of this disease with various developmental mechanisms and associated manifestations. Clinical case description. This article presents the patient admitted with diagnosis and clinical picture of pachydermia, who underwent surgical excision of scalp abnormal tissues. However, the diagnosis of giant congenital melanocytic nevus was established according to the results of clinical examination. Later it was confirmed by histological and immunohistological studies. Moreover, pathogenic variants in the NRAS gene were not revealed. Conclusion. This case demonstrates the complexity of differential diagnosis of pachydermia that leads to careful examination of patients with morphogenetic studies of affected tissues samples. |
| format | Article |
| id | doaj-art-08ab8be97feb48e78ab3bfeab5c1af10 |
| institution | Matheson Library |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-08ab8be97feb48e78ab3bfeab5c1af102025-08-04T13:09:43Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352024-11-0123535636210.15690/vsp.v23i5.27922200Cutis Verticis Gyrata Differential Diagnosis: Clinical CaseTatiana S. Belysheva0Ekaterina E. Zelenova1Tatiana A. Gassan2Eduard T. Ambarchyan3Malika I. Denieva4Yana V. Vishnevskaya5Tatiana V. Nasedkina6Nikolay N. Murashkin7National Medical Research Center of Oncology named after N.N. BlokhinNational Medical Research Center of Oncology named after N.N. Blokhin; Engelhardt Institute of Molecular BiologyRussian Children’s Clinical Hospital, Pirogov Russian National Research Medical UniversityResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of SurgeryRepublican Dermatovenerologic Dispensary; Kadyrov Chechen State UniversityNational Medical Research Center of Oncology named after N.N. BlokhinEngelhardt Institute of Molecular BiologyNational Medical Research Center of Children’s Health; Sechenov First Moscow State Medical University;Central State Medical Academy of Department of Presidential AffairsBackground. Cutis verticis gyrata is rare benign scalp disorder characterized by excessive skin and subcutaneous tissue proliferation and hypertrophy. Nowadays, there are three forms of this disease with various developmental mechanisms and associated manifestations. Clinical case description. This article presents the patient admitted with diagnosis and clinical picture of pachydermia, who underwent surgical excision of scalp abnormal tissues. However, the diagnosis of giant congenital melanocytic nevus was established according to the results of clinical examination. Later it was confirmed by histological and immunohistological studies. Moreover, pathogenic variants in the NRAS gene were not revealed. Conclusion. This case demonstrates the complexity of differential diagnosis of pachydermia that leads to careful examination of patients with morphogenetic studies of affected tissues samples.https://vsp.spr-journal.ru/jour/article/view/3609clinical casecutis verticis gyratagiant congenital melanocytic nevusimmunohistological studymelan aр16nras |
| spellingShingle | Tatiana S. Belysheva Ekaterina E. Zelenova Tatiana A. Gassan Eduard T. Ambarchyan Malika I. Denieva Yana V. Vishnevskaya Tatiana V. Nasedkina Nikolay N. Murashkin Cutis Verticis Gyrata Differential Diagnosis: Clinical Case Вопросы современной педиатрии clinical case cutis verticis gyrata giant congenital melanocytic nevus immunohistological study melan a р16 nras |
| title | Cutis Verticis Gyrata Differential Diagnosis: Clinical Case |
| title_full | Cutis Verticis Gyrata Differential Diagnosis: Clinical Case |
| title_fullStr | Cutis Verticis Gyrata Differential Diagnosis: Clinical Case |
| title_full_unstemmed | Cutis Verticis Gyrata Differential Diagnosis: Clinical Case |
| title_short | Cutis Verticis Gyrata Differential Diagnosis: Clinical Case |
| title_sort | cutis verticis gyrata differential diagnosis clinical case |
| topic | clinical case cutis verticis gyrata giant congenital melanocytic nevus immunohistological study melan a р16 nras |
| url | https://vsp.spr-journal.ru/jour/article/view/3609 |
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