Next-Generation Sequencing Reveals the Potential Role of RET Protooncogene in Metastasis Progression in Medullary Thyroid Cancer

Next-Generation Sequencing Reveals the Potential Role of RET Protooncogene in Metastasis Progression in Medullary Thyroid Cancer

<b>Background:</b> Medullary thyroid carcinoma (MTC) has a high rate of local and distant metastases. In particular, the RET protooncogene appears to be the predominant driver mutation for oncogenesis. The German S3 thyroid carcinoma guidelines recommend molecular genetic analysis of the...

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Bibliographic Details
Main Authors: Maurice Klein, Anna Julia Claudia Klein, Arnold M. Raem, Nicklas Garrelfs, Henrike J. Fischer, Frank Hölzle, Kai Wermker
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Current Issues in Molecular Biology
Subjects:
MTC
thyroid cancer
metastasis
medullary thyroid cancer
RET
Online Access:https://www.mdpi.com/1467-3045/47/7/560
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