An In vivo Metabolic Reaction-Based Mass Difference Screening Strategy for Comprehensive Metabolite Profiling of the Huangqi-Danshen Herb Pair Using Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole-Time-of-Flight Mass Spectrometry

An In vivo Metabolic Reaction-Based Mass Difference Screening Strategy for Comprehensive Metabolite Profiling of the Huangqi-Danshen Herb Pair Using Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole-Time-of-Flight Mass Spectrometry

Objective: The absorbed prototypes and metabolites of traditional Chinese medicines in vivo are crucial for identifying their biological functions. However, comprehensive profiling of constituents in vivo is difficult owing to endogenous interference and low metabolite abundance. Therefore, a system...

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Bibliographic Details
Main Authors: Chen-Xi Liu, Xin-Lu Li, Cai-Yi Ma, Meng Ding, Ping Li, Hua Yang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-04-01
Series:World Journal of Traditional Chinese Medicine
Subjects:
database screening
huangqi-danshen herb pair
mass difference
metabolite profiling
ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry
Online Access:https://journals.lww.com/10.4103/wjtcm.wjtcm_4_25
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