Enhanced extracellular matrix remodeling due to embedded spheroid fluidization

Embedding a collective of tumor cells, i.e. a tumor spheroid, in a fibrous environment, such as a collagen network, provides an essential in vitro platform to investigate the biophysical mechanisms of tumor invasion. To predict new mechanisms, we develop a three-dimensional computational model of an...

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Bibliographic Details
Main Authors: Tao Zhang, Shabeeb Ameen, Sounok Ghosh, Kyungeun Kim, Mrinal Pandey, Brian C H Cheung, Minh Thanh, Alison E Patteson, Mingming Wu, J M Schwarz
Format: Article
Language:English
Published: IOP Publishing 2025-01-01
Series:New Journal of Physics
Subjects:
Online Access:https://doi.org/10.1088/1367-2630/ade81e
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