Opportunities proteomic the analysis of fibers of urine for an estimation of progressing of a chronic heart failure
Purpose: To reveal, what changes of fibers of a pattern of urine at sick are connected by a chronic heart failure (CHF) with increase of a functional class (FC) of disease.Materials and Methods: 90 patients with CHF II-IV FC are surveyed. Control group practically healthy 30 patients. Differentiated...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2011-03-01
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| Series: | Медицинский вестник Юга России |
| Subjects: | |
| Online Access: | https://www.medicalherald.ru/jour/article/view/1174 |
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| Summary: | Purpose: To reveal, what changes of fibers of a pattern of urine at sick are connected by a chronic heart failure (CHF) with increase of a functional class (FC) of disease.Materials and Methods: 90 patients with CHF II-IV FC are surveyed. Control group practically healthy 30 patients. Differentiated allocation separate proteins and fibers of urine of patients made by means of weights-spectrometry.Results: At patients CHF in structure of fibers of urine markers of alteration of kidneys, connected with structural transformation. Progressing CHF up to a final stage it is connected with increase of occurrence β-sarcoglican, similar to tolloids fiber 2 and L-antigen. Among contracting fibers in process of increase FC CHFoccurrence cation-transport ATP decreases, and isoforms 1 fiber 6, connected with microtubuls – raises, that causes reduction of activity of receipt of calcium in sarcoplasmic rethiculum in nephrocytes and endoteliocytes vessels of kidneys.Summary: Changes of an albuminous spectrum of urine at patients CHF it is information are significant for the forecast of progressing of a basic disease. |
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| ISSN: | 2219-8075 2618-7876 |