Sensitivity analysis of a mathematical model of Alzheimer's disease progression unveils important causal pathways

Sensitivity analysis of a mathematical model of Alzheimer's disease progression unveils important causal pathways

IntroductionMathematical models serve as essential tools to investigate brain aging, the onset of Alzheimer's disease (AD) and its progression. By studying the representation of the complex dynamics of brain aging processes, such as amyloid beta (Aβ) deposition, tau tangles, neuro-inflammation,...

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Bibliographic Details
Main Authors: Seyedadel Moravveji, Halima Sadia, Nicolas Doyon, Simon Duchesne
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Neuroinformatics
Subjects:
Alzheimer's disease
mathematical models
neural density
sensitivity analysis
amyloid beta
tau proteins
Online Access:https://www.frontiersin.org/articles/10.3389/fninf.2025.1590968/full
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https://www.frontiersin.org/articles/10.3389/fninf.2025.1590968/full

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