Alcohol zero: the end, the beginning of the end, or just the end of the beginning?
Alcohol drinks, especially wine, have been described since 6,000 B.C. For many years in modern medicine, wine in moderation has been considered healthy for cardiovascular prevention, i.e., recommended by nutrition committees. Some regional guidelines still recommend one to two standard drinks per da...
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Open Exploration Publishing Inc.
2023-08-01
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| Sraith: | Exploration of Cardiology |
| Ábhair: | |
| Rochtain ar líne: | https://www.explorationpub.com/uploads/Article/A10125/10125.pdf |
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| _version_ | 1839629639533723648 |
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| author | Miodrag Ostojic Vlado Djajic Tamara Kovacevic-Preradovic Dusko Vulic |
| author_facet | Miodrag Ostojic Vlado Djajic Tamara Kovacevic-Preradovic Dusko Vulic |
| author_sort | Miodrag Ostojic |
| collection | DOAJ |
| description | Alcohol drinks, especially wine, have been described since 6,000 B.C. For many years in modern medicine, wine in moderation has been considered healthy for cardiovascular prevention, i.e., recommended by nutrition committees. Some regional guidelines still recommend one to two standard drinks per day. By the very recent (January 2023), World Health Organization and Canadian Guidance on alcohol emphasize that any alcoholic drink is hazardous to the health and the safe amount is zero. The risk starts with every single drop. It was also nicely summarized in the manuscript “Alcohol-dose question and the weakest link in a chemical interplay” (Explor Cardiol. 2023;1:15–25. doi: 10.37349/ec.2023.00003) especially from the standpoint of a researcher in the cardiovascular arena. The newest recommendations are based on observational studies and their meta-analysis, therefore establishing associations, pointing out that alcohol may somewhat prevent cardiovascular diseases and diabetes type 2, but with a significant increase in non-cardiovascular morbidity and mortality, especially cancers. Previous recommendations, therefore, may be obsolete as they were based on studies where abstainers from alcoholic beverages had inherent higher risks. The current controversy with conflicting guidelines for alcoholic beverage consumption in the era of precision medicine may stimulate more fundamental investigations up to genetic ones and find the cause-effect relations. In the era of precision medicine, it may come closer to discovering the causes of cancers and many other diseases, enabling predictions of reactions to alcoholic beverages by each person, not just in the population. |
| format | Article |
| id | doaj-art-05923e503b8a4f0b8c6c2e582737bf3a |
| institution | Matheson Library |
| issn | 2994-5526 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Cardiology |
| spelling | doaj-art-05923e503b8a4f0b8c6c2e582737bf3a2025-07-15T02:12:18ZengOpen Exploration Publishing Inc.Exploration of Cardiology2994-55262023-08-0111354110.37349/ec.2023.00005Alcohol zero: the end, the beginning of the end, or just the end of the beginning?Miodrag Ostojic0https://orcid.org/0000-0002-1250-7461Vlado Djajic1Tamara Kovacevic-Preradovic2https://orcid.org/0000-0002-7100-5189Dusko Vulic3https://orcid.org/0000-0001-6661-904XDepartment of Cardiology, University of Belgrade and Serbian Heart Foundation, 11000 Belgrade, SerbiaDepartment of Neurology, Medical Faculty, University of Banja Luka, 51000 Banja Luka, Bosnia and HerzegovinaDepartment of Neurology, Medical Faculty, University of Banja Luka, 51000 Banja Luka, Bosnia and HerzegovinaDepartment of Neurology, Medical Faculty, University of Banja Luka, 51000 Banja Luka, Bosnia and HerzegovinaAlcohol drinks, especially wine, have been described since 6,000 B.C. For many years in modern medicine, wine in moderation has been considered healthy for cardiovascular prevention, i.e., recommended by nutrition committees. Some regional guidelines still recommend one to two standard drinks per day. By the very recent (January 2023), World Health Organization and Canadian Guidance on alcohol emphasize that any alcoholic drink is hazardous to the health and the safe amount is zero. The risk starts with every single drop. It was also nicely summarized in the manuscript “Alcohol-dose question and the weakest link in a chemical interplay” (Explor Cardiol. 2023;1:15–25. doi: 10.37349/ec.2023.00003) especially from the standpoint of a researcher in the cardiovascular arena. The newest recommendations are based on observational studies and their meta-analysis, therefore establishing associations, pointing out that alcohol may somewhat prevent cardiovascular diseases and diabetes type 2, but with a significant increase in non-cardiovascular morbidity and mortality, especially cancers. Previous recommendations, therefore, may be obsolete as they were based on studies where abstainers from alcoholic beverages had inherent higher risks. The current controversy with conflicting guidelines for alcoholic beverage consumption in the era of precision medicine may stimulate more fundamental investigations up to genetic ones and find the cause-effect relations. In the era of precision medicine, it may come closer to discovering the causes of cancers and many other diseases, enabling predictions of reactions to alcoholic beverages by each person, not just in the population.https://www.explorationpub.com/uploads/Article/A10125/10125.pdfalcoholic beveragesred winecardiovascular mortalitynon-cardiovascular mortality |
| spellingShingle | Miodrag Ostojic Vlado Djajic Tamara Kovacevic-Preradovic Dusko Vulic Alcohol zero: the end, the beginning of the end, or just the end of the beginning? Exploration of Cardiology alcoholic beverages red wine cardiovascular mortality non-cardiovascular mortality |
| title | Alcohol zero: the end, the beginning of the end, or just the end of the beginning? |
| title_full | Alcohol zero: the end, the beginning of the end, or just the end of the beginning? |
| title_fullStr | Alcohol zero: the end, the beginning of the end, or just the end of the beginning? |
| title_full_unstemmed | Alcohol zero: the end, the beginning of the end, or just the end of the beginning? |
| title_short | Alcohol zero: the end, the beginning of the end, or just the end of the beginning? |
| title_sort | alcohol zero the end the beginning of the end or just the end of the beginning |
| topic | alcoholic beverages red wine cardiovascular mortality non-cardiovascular mortality |
| url | https://www.explorationpub.com/uploads/Article/A10125/10125.pdf |
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