Synthesis and Evaluation of Novel 5-Arylidene-2-(7-chloroquinolin-6-yl)-3-(pyrimidin-2-yl) Thiazolidin-4-Ones as Anti-Microbial Agents
The development of combination chemotherapeutic drugs, each with distinct mechanisms and minimal side effects, is crucial in combating antimicrobial resistance. Discovering novel drugs with diverse mechanisms is laborious and time-consuming. Alternatively, combining multiple pharmacophores into a si...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
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| Series: | Chemistry Proceedings |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4583/16/1/51 |
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| Summary: | The development of combination chemotherapeutic drugs, each with distinct mechanisms and minimal side effects, is crucial in combating antimicrobial resistance. Discovering novel drugs with diverse mechanisms is laborious and time-consuming. Alternatively, combining multiple pharmacophores into a single molecule offers a promising strategy to develop more effective treatments. In this study, we synthesized and assessed the antimicrobial activity of novel 5-arylidene-2-(7-chloroquinolin-6-yl)-3-(pyrimidin-2-yl) thiazolidin-4-ones. |
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| ISSN: | 2673-4583 |