Evaluation of Some Antioxidants and Oxidative Stress Tests in Iraqi Lung Cancer Patients
Vitamin K-dependent protein (VKDP) contributes to the development of lung cancer. The purpose of this research was to better understanding of the role of blood matrix Gla protein (MGP), VKDPs, Malondialdehyde (MDA), Superoxide dismutase (SOD) and Vitamin K (Vit K) in Iraqi patients with lung cancer...
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University of Baghdad, College of Science for Women
2022-11-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7597 |
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| author | Israa F. Ascar Fayhaa M. Khaleel Areej Sh. Hameed Musaab Kadhim Alabboodi |
| author_facet | Israa F. Ascar Fayhaa M. Khaleel Areej Sh. Hameed Musaab Kadhim Alabboodi |
| author_sort | Israa F. Ascar |
| collection | DOAJ |
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Vitamin K-dependent protein (VKDP) contributes to the development of lung cancer. The purpose of this research was to better understanding of the role of blood matrix Gla protein (MGP), VKDPs, Malondialdehyde (MDA), Superoxide dismutase (SOD) and Vitamin K (Vit K) in Iraqi patients with lung cancer before and after the first cycle of chemotherapy. Blood samples were collected from Al amal National Hospital for cancer treatment from October 2021 to May 2022, and a total of 80 samples were collected, divided into two groups (40 patient before taking a chemotherapy and 40 patients after taking chemotherapy), ranging in age from 20 to 45 years old. The results showed that although there were highly statistically significant differences in MDA, VKDPS, SOD, and Vit K, there was no difference in MGP serum levels between the two groups (P = 0.05). The current study found a significant positive correlation between MGP and VK1 values.Correlations before and after treatment. Based on the results obtained, no role for the blood matrix protein Gla was observed in patients after and before treatment. Therefore, it cannot be considered a sign of patients' response to treatment. In addition, it was observed that lung cancer patients had lower levels of SOD enzyme, which indicates the effect of treatment on the disease, in which knowing the extent to which the body is responding or not responding to treatment.
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| format | Article |
| id | doaj-art-03ee7dfdf4f84eaa9fb625d90f0b5df1 |
| institution | Matheson Library |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-03ee7dfdf4f84eaa9fb625d90f0b5df12025-08-02T00:26:37ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862022-11-01196(Suppl.)10.21123/bsj.2022.7597Evaluation of Some Antioxidants and Oxidative Stress Tests in Iraqi Lung Cancer PatientsIsraa F. Ascar0Fayhaa M. Khaleel1Areej Sh. Hameed2Musaab Kadhim Alabboodi3Department of Chemistry, College of Science for Woman, University of Baghdad, Baghdad, Iraq.Department of Chemistry, College of Science for Woman, University of Baghdad, Baghdad, Iraq.Department of Chemistry, College of Science for Woman, University of Baghdad, Baghdad, Iraq.FICMS, Medical Oncology, MOH/Medical City, Al amal National Hospital for cancer treatment. Vitamin K-dependent protein (VKDP) contributes to the development of lung cancer. The purpose of this research was to better understanding of the role of blood matrix Gla protein (MGP), VKDPs, Malondialdehyde (MDA), Superoxide dismutase (SOD) and Vitamin K (Vit K) in Iraqi patients with lung cancer before and after the first cycle of chemotherapy. Blood samples were collected from Al amal National Hospital for cancer treatment from October 2021 to May 2022, and a total of 80 samples were collected, divided into two groups (40 patient before taking a chemotherapy and 40 patients after taking chemotherapy), ranging in age from 20 to 45 years old. The results showed that although there were highly statistically significant differences in MDA, VKDPS, SOD, and Vit K, there was no difference in MGP serum levels between the two groups (P = 0.05). The current study found a significant positive correlation between MGP and VK1 values.Correlations before and after treatment. Based on the results obtained, no role for the blood matrix protein Gla was observed in patients after and before treatment. Therefore, it cannot be considered a sign of patients' response to treatment. In addition, it was observed that lung cancer patients had lower levels of SOD enzyme, which indicates the effect of treatment on the disease, in which knowing the extent to which the body is responding or not responding to treatment. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7597Blood matrix Gla protein (MGP), Chemotherapy, Lung cancer, Malondialdehyde (MDA), Superoxide dismutase (SOD), Vitamin K (vit. K) |
| spellingShingle | Israa F. Ascar Fayhaa M. Khaleel Areej Sh. Hameed Musaab Kadhim Alabboodi Evaluation of Some Antioxidants and Oxidative Stress Tests in Iraqi Lung Cancer Patients مجلة بغداد للعلوم Blood matrix Gla protein (MGP), Chemotherapy, Lung cancer, Malondialdehyde (MDA), Superoxide dismutase (SOD), Vitamin K (vit. K) |
| title | Evaluation of Some Antioxidants and Oxidative Stress Tests in Iraqi Lung Cancer Patients |
| title_full | Evaluation of Some Antioxidants and Oxidative Stress Tests in Iraqi Lung Cancer Patients |
| title_fullStr | Evaluation of Some Antioxidants and Oxidative Stress Tests in Iraqi Lung Cancer Patients |
| title_full_unstemmed | Evaluation of Some Antioxidants and Oxidative Stress Tests in Iraqi Lung Cancer Patients |
| title_short | Evaluation of Some Antioxidants and Oxidative Stress Tests in Iraqi Lung Cancer Patients |
| title_sort | evaluation of some antioxidants and oxidative stress tests in iraqi lung cancer patients |
| topic | Blood matrix Gla protein (MGP), Chemotherapy, Lung cancer, Malondialdehyde (MDA), Superoxide dismutase (SOD), Vitamin K (vit. K) |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7597 |
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