Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas
The concentrations of matrix metalloproteinases (MMP-2, -3, -9) and their tissue inhibitors (TIMP-1, -2) were studied in blood serum of 193 patients with squamous cell head and neck carcinoma (SCHNC) and in 38 healthy donors using immunoenzymatic assay. The decreased MMP-3 and TIMP-1, -2 levels were...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2011-02-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/1315 |
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| author | Ye. V. Klisho I. V. Kondakova Ye. L. Choynzonov O. V. Cheremisina D. A. Shishkin |
| author_facet | Ye. V. Klisho I. V. Kondakova Ye. L. Choynzonov O. V. Cheremisina D. A. Shishkin |
| author_sort | Ye. V. Klisho |
| collection | DOAJ |
| description | The concentrations of matrix metalloproteinases (MMP-2, -3, -9) and their tissue inhibitors (TIMP-1, -2) were studied in blood serum of 193 patients with squamous cell head and neck carcinoma (SCHNC) and in 38 healthy donors using immunoenzymatic assay. The decreased MMP-3 and TIMP-1, -2 levels were found in patients with oral cavity tumors as compared to patients with laryngeal cancer. The serum MMP-9 and TIMP-1 levels were significantly higher in head and neck cancer patients than in healthy subjects. High TIMP-1 and MMP-9 levels in blood serum of patients with SCHNC should be greatly attended for detection of their predictive and prognostic significances. |
| format | Article |
| id | doaj-art-03ab34a41f5e4d0c95b9d7b097eba8c5 |
| institution | Matheson Library |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2011-02-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-03ab34a41f5e4d0c95b9d7b097eba8c52025-08-04T16:45:32ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842011-02-01101555810.20538/1682-0363-2011-1-55-58838Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomasYe. V. Klisho0I. V. Kondakova1Ye. L. Choynzonov2O. V. Cheremisina3D. A. Shishkin4НИИ онкологии СО РАМННИИ онкологии СО РАМННИИ онкологии СО РАМН; Сибирский государственный медицинский университетНИИ онкологии СО РАМННИИ онкологии СО РАМНThe concentrations of matrix metalloproteinases (MMP-2, -3, -9) and their tissue inhibitors (TIMP-1, -2) were studied in blood serum of 193 patients with squamous cell head and neck carcinoma (SCHNC) and in 38 healthy donors using immunoenzymatic assay. The decreased MMP-3 and TIMP-1, -2 levels were found in patients with oral cavity tumors as compared to patients with laryngeal cancer. The serum MMP-9 and TIMP-1 levels were significantly higher in head and neck cancer patients than in healthy subjects. High TIMP-1 and MMP-9 levels in blood serum of patients with SCHNC should be greatly attended for detection of their predictive and prognostic significances.https://bulletin.ssmu.ru/jour/article/view/1315squamous cell head and neck carcinomamatrix metalloproteinasestissue inhibitors of matrix metalloproteinases |
| spellingShingle | Ye. V. Klisho I. V. Kondakova Ye. L. Choynzonov O. V. Cheremisina D. A. Shishkin Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas Бюллетень сибирской медицины squamous cell head and neck carcinoma matrix metalloproteinases tissue inhibitors of matrix metalloproteinases |
| title | Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas |
| title_full | Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas |
| title_fullStr | Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas |
| title_full_unstemmed | Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas |
| title_short | Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas |
| title_sort | matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas |
| topic | squamous cell head and neck carcinoma matrix metalloproteinases tissue inhibitors of matrix metalloproteinases |
| url | https://bulletin.ssmu.ru/jour/article/view/1315 |
| work_keys_str_mv | AT yevklisho matrixmetalloproteinasesysteminbloodseruminpatientswithsquamouscellheadandneckcarcinomas AT ivkondakova matrixmetalloproteinasesysteminbloodseruminpatientswithsquamouscellheadandneckcarcinomas AT yelchoynzonov matrixmetalloproteinasesysteminbloodseruminpatientswithsquamouscellheadandneckcarcinomas AT ovcheremisina matrixmetalloproteinasesysteminbloodseruminpatientswithsquamouscellheadandneckcarcinomas AT dashishkin matrixmetalloproteinasesysteminbloodseruminpatientswithsquamouscellheadandneckcarcinomas |