Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas
The concentrations of matrix metalloproteinases (MMP-2, -3, -9) and their tissue inhibitors (TIMP-1, -2) were studied in blood serum of 193 patients with squamous cell head and neck carcinoma (SCHNC) and in 38 healthy donors using immunoenzymatic assay. The decreased MMP-3 and TIMP-1, -2 levels were...
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Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Siberian State Medical University (Tomsk)
2011-02-01
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Series: | Бюллетень сибирской медицины |
Subjects: | |
Online Access: | https://bulletin.ssmu.ru/jour/article/view/1315 |
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Summary: | The concentrations of matrix metalloproteinases (MMP-2, -3, -9) and their tissue inhibitors (TIMP-1, -2) were studied in blood serum of 193 patients with squamous cell head and neck carcinoma (SCHNC) and in 38 healthy donors using immunoenzymatic assay. The decreased MMP-3 and TIMP-1, -2 levels were found in patients with oral cavity tumors as compared to patients with laryngeal cancer. The serum MMP-9 and TIMP-1 levels were significantly higher in head and neck cancer patients than in healthy subjects. High TIMP-1 and MMP-9 levels in blood serum of patients with SCHNC should be greatly attended for detection of their predictive and prognostic significances. |
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ISSN: | 1682-0363 1819-3684 |