Prognostic and clinicopathological role of long non-coding RNA taurine upregulated 1 in various human malignancies: A systemic review and meta-analysis
The aberrant dysregulation of taurine upregulated 1, a novel discovered long non-coding RNA, was ubiquitous in different human solid tumors. Accumulating researches have indicated that taurine upregulated 1 is an independent prognostic indicator in cancer patients. This investigation aimed to furthe...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-06-01
|
| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317714361 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839644411822080000 |
|---|---|
| author | Xiaoxiong Wang Xin Chen Daming Zhang Guang Yang Zhao Yang Zhiqin Yin Shiguang Zhao |
| author_facet | Xiaoxiong Wang Xin Chen Daming Zhang Guang Yang Zhao Yang Zhiqin Yin Shiguang Zhao |
| author_sort | Xiaoxiong Wang |
| collection | DOAJ |
| description | The aberrant dysregulation of taurine upregulated 1, a novel discovered long non-coding RNA, was ubiquitous in different human solid tumors. Accumulating researches have indicated that taurine upregulated 1 is an independent prognostic indicator in cancer patients. This investigation aimed to further explore the prognostic and clinical significance of taurine upregulated 1 in various types of cancers. Eligible studies were systematically searched in PubMed, Embase, Medline, and Web of Science databases. A total of 12/14 studies with 1303/1228 individuals were included to evaluate the association of taurine upregulated 1 with overall survival and clinicopathological features by pooled hazard ratio and odds ratio in malignancies. The meta-analysis suggested overexpression of taurine upregulated 1 was significantly correlated with unfavorable overall survival in patients with cancer (pooled hazard ratio = 1.63, 95% confidence interval: 1.29–2.06). There was also a significantly positive correlation between high level of taurine upregulated 1 and high pathological grade carcinoma (pooled odds ratio = 4.41, 95% confidence interval: 3.07–6.43) and positive lymphatic metastasis (pooled odds ratio = 2.00, 95% confidence interval: 1.31–3.06). In summary, upregulated taurine upregulated 1 is correlated with more advanced clinicopathological characteristics and poor prognosis, suggesting that taurine upregulated 1 may serve as a novel predictive biomarker of patients with numerous tumors. |
| format | Article |
| id | doaj-art-036120c75b1d4bcb9eee8829e0ce914c |
| institution | Matheson Library |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-036120c75b1d4bcb9eee8829e0ce914c2025-07-02T00:28:24ZengSAGE PublishingTumor Biology1423-03802017-06-013910.1177/1010428317714361Prognostic and clinicopathological role of long non-coding RNA taurine upregulated 1 in various human malignancies: A systemic review and meta-analysisXiaoxiong Wang0Xin Chen1Daming Zhang2Guang Yang3Zhao Yang4Zhiqin Yin5Shiguang Zhao6Institute of Brain Science, Harbin Medical University, Harbin, People’s Republic of ChinaInstitute of Brain Science, Harbin Medical University, Harbin, People’s Republic of ChinaInstitute of Brain Science, Harbin Medical University, Harbin, People’s Republic of ChinaInstitute of Brain Science, Harbin Medical University, Harbin, People’s Republic of ChinaInstitute of Brain Science, Harbin Medical University, Harbin, People’s Republic of ChinaInstitute of Brain Science, Harbin Medical University, Harbin, People’s Republic of ChinaInstitute of Brain Science, Harbin Medical University, Harbin, People’s Republic of ChinaThe aberrant dysregulation of taurine upregulated 1, a novel discovered long non-coding RNA, was ubiquitous in different human solid tumors. Accumulating researches have indicated that taurine upregulated 1 is an independent prognostic indicator in cancer patients. This investigation aimed to further explore the prognostic and clinical significance of taurine upregulated 1 in various types of cancers. Eligible studies were systematically searched in PubMed, Embase, Medline, and Web of Science databases. A total of 12/14 studies with 1303/1228 individuals were included to evaluate the association of taurine upregulated 1 with overall survival and clinicopathological features by pooled hazard ratio and odds ratio in malignancies. The meta-analysis suggested overexpression of taurine upregulated 1 was significantly correlated with unfavorable overall survival in patients with cancer (pooled hazard ratio = 1.63, 95% confidence interval: 1.29–2.06). There was also a significantly positive correlation between high level of taurine upregulated 1 and high pathological grade carcinoma (pooled odds ratio = 4.41, 95% confidence interval: 3.07–6.43) and positive lymphatic metastasis (pooled odds ratio = 2.00, 95% confidence interval: 1.31–3.06). In summary, upregulated taurine upregulated 1 is correlated with more advanced clinicopathological characteristics and poor prognosis, suggesting that taurine upregulated 1 may serve as a novel predictive biomarker of patients with numerous tumors.https://doi.org/10.1177/1010428317714361 |
| spellingShingle | Xiaoxiong Wang Xin Chen Daming Zhang Guang Yang Zhao Yang Zhiqin Yin Shiguang Zhao Prognostic and clinicopathological role of long non-coding RNA taurine upregulated 1 in various human malignancies: A systemic review and meta-analysis Tumor Biology |
| title | Prognostic and clinicopathological role of long non-coding RNA taurine upregulated 1 in various human malignancies: A systemic review and meta-analysis |
| title_full | Prognostic and clinicopathological role of long non-coding RNA taurine upregulated 1 in various human malignancies: A systemic review and meta-analysis |
| title_fullStr | Prognostic and clinicopathological role of long non-coding RNA taurine upregulated 1 in various human malignancies: A systemic review and meta-analysis |
| title_full_unstemmed | Prognostic and clinicopathological role of long non-coding RNA taurine upregulated 1 in various human malignancies: A systemic review and meta-analysis |
| title_short | Prognostic and clinicopathological role of long non-coding RNA taurine upregulated 1 in various human malignancies: A systemic review and meta-analysis |
| title_sort | prognostic and clinicopathological role of long non coding rna taurine upregulated 1 in various human malignancies a systemic review and meta analysis |
| url | https://doi.org/10.1177/1010428317714361 |
| work_keys_str_mv | AT xiaoxiongwang prognosticandclinicopathologicalroleoflongnoncodingrnataurineupregulated1invarioushumanmalignanciesasystemicreviewandmetaanalysis AT xinchen prognosticandclinicopathologicalroleoflongnoncodingrnataurineupregulated1invarioushumanmalignanciesasystemicreviewandmetaanalysis AT damingzhang prognosticandclinicopathologicalroleoflongnoncodingrnataurineupregulated1invarioushumanmalignanciesasystemicreviewandmetaanalysis AT guangyang prognosticandclinicopathologicalroleoflongnoncodingrnataurineupregulated1invarioushumanmalignanciesasystemicreviewandmetaanalysis AT zhaoyang prognosticandclinicopathologicalroleoflongnoncodingrnataurineupregulated1invarioushumanmalignanciesasystemicreviewandmetaanalysis AT zhiqinyin prognosticandclinicopathologicalroleoflongnoncodingrnataurineupregulated1invarioushumanmalignanciesasystemicreviewandmetaanalysis AT shiguangzhao prognosticandclinicopathologicalroleoflongnoncodingrnataurineupregulated1invarioushumanmalignanciesasystemicreviewandmetaanalysis |