Immunological aspects of the lethal HIV / COVID-19 coinfected cohort

Immunological aspects of the lethal HIV / COVID-19 coinfected cohort

SARS-CoV-2 pandemic is now a global medical and social problem. Little is known about its impact on some vulnerable subgroups, such as immunocompromised patients. Therefore, there is still a strong interest in exploring the impact of SARS-CoV-2 infection among HIV-positive individuals worldwide.   A...

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Main Authors: A. I. Mazus, E. V. Tsyganova, A. S. Zhilenkova, N. V. Glukhoedova, M. D. Geyne, Yu. A. Anikina, Yu. G. Parkhomenko, N. V. Mozgaleva, P. A. Vedyapin, O. A. Tishkevich
Format: Article
Language:Russian
Published: Journal Infectology 2023-01-01
Series:Журнал инфектологии
Subjects:
covid-19
hiv-infection
cd4+ lymphocytes
cd8+ lymphocytes
immunity
Online Access:https://journal.niidi.ru/jofin/article/view/1423
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Summary:SARS-CoV-2 pandemic is now a global medical and social problem. Little is known about its impact on some vulnerable subgroups, such as immunocompromised patients. Therefore, there is still a strong interest in exploring the impact of SARS-CoV-2 infection among HIV-positive individuals worldwide.   Aim of the study: to analyze immunological aspects of the deceased patients with HIV/COVID-19 coinfection.   Materials and methods. We provided retrospective analysis of 258 patient’s electronic medical records. All patients were admitted to the Infectious diseases hospital № 2 with HIV / COVID-19 coinfection and died in May 2020 – February 2022. Standard immunological parameters were analyzed like CD4+, CD8+ counts and immunoregulatory index for different patient’s subgroups. Statistical data processing was provided by SPSS 17 version (allowable error E = 5 %).   Results and discussion. The study demonstrated CD4+ and CD8+ reduction in HIV-infected with COVID-19. Late HIV-presenters didn’t display such phenomenon probably because of immune system exhaustion. COVID-19 itself in some cases could lead to immunodeficiency worsening due to depletion of T cell populations in HIV-patients on effective antiretroviral therapy.   Conclusion. Comprehension of different immunological characteristics in HIV / COVID-19 coinfected patients could improve therapeutic approaches for this challenging cohort.
ISSN:2072-6732

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